How does FIR irradiation specifically upregulate TRPV3 expression at the molecular level?

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Description

The study shows FIR upregulates TRPV3 expression leading to Ca2+ influx, but the direct molecular mechanisms by which FIR radiation influences TRPV3 gene/protein expression remain unexplained. Understanding this mechanism is crucial for optimizing therapeutic FIR protocols and identifying potential off-target effects.

Gap type: unexplained_observation Source paper: Far-infrared irradiation suppresses pyroptosis in ischemic flaps through TRPV3-mediated activation of the A2AR/EPAC1/Rap1 signaling pathway. (2026, Cellular signalling, PMID:41354356)

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