What determines the specificity of LINC01956-FUS interaction versus other RNA-binding proteins?

molecular neurobiology open
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Description

While the study demonstrates LINC01956 binds FUS and reduces its ubiquitination, the molecular basis for this specific interaction remains unclear. This gap limits understanding of how lncRNAs selectively regulate protein stability and could inform therapeutic targeting strategies.

Gap type: unexplained_observation Source paper: Ailanthone disturbs cross-talk between cancer cells and tumor-associated macrophages via HIF1-α/LINC01956/FUS/β-catenin signaling pathway in glioblastoma. (None, None, PMID:39639311)

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