How does ailanthone selectively cross the blood-brain barrier and target glioma tissue?

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Description

The abstract reports that ailanthone exhibits BBB permeability and specifically targets tumor areas, but provides no mechanistic explanation for this selective targeting. Understanding this mechanism is crucial for developing brain-targeted therapeutics and could reveal new approaches for drug delivery across the BBB.

Gap type: unexplained_observation Source paper: Ailanthone disturbs cross-talk between cancer cells and tumor-associated macrophages via HIF1-α/LINC01956/FUS/β-catenin signaling pathway in glioblastoma. (None, None, PMID:39639311)

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