What determines the cell-type specificity of ABCA7 variant effects despite widespread expression?

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Description

While the study shows widespread gene expression changes across multiple neural cell types, excitatory neurons show the most severe disruptions despite ABCA7 being expressed in other cell types. The molecular basis for this selective vulnerability remains unexplained, yet could inform targeted therapeutic strategies.

Gap type: unexplained_observation Source paper: ABCA7 variants impact phosphatidylcholine and mitochondria in neurons. (2025, Nature, PMID:40931065)

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