What mechanisms explain PM₂.₅-induced tau pathology in APOE4+ carriers independent of neuroinflammation?

neuroinflammation open
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Description

The study explicitly shows neuroinflammation does not mediate the PM₂.₅-tau relationship in APOE4+ carriers, contradicting the prevailing hypothesis that air pollution acts through inflammatory pathways. Alternative molecular mechanisms remain unidentified.

Gap type: contradiction Source paper: Associations between air pollution and markers of neuroinflammation, synaptic dysfunction and core Alzheimer’s disease pathology vary by APOE genotype. (2026, Neurotoxicity research, PMID:41944915)

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