What determines the brain-specific predilection of CCM lesions despite systemic CCM gene expression?

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Description

While the study shows CCM3 loss disrupts blood-brain barrier integrity as an inciting event, it doesn’t explain why CCM lesions predominantly form in brain vasculature when CCM genes are expressed throughout the body. This brain-specific vulnerability remains mechanistically unclear.

Gap type: unexplained_observation Source paper: mTORC1 Signaling in Brain Endothelial Progenitors Contributes to CCM Pathogenesis. (2024, Circulation research, PMID:38957991)

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