What signals trigger the clonal expansion of specific venous capillary ECs/EPCs to initiate CCM lesion formation?

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Description

The study confirms CCM lesions derive from clonal expansion of angiogenic venous capillary ECs and EPCs, but the upstream signaling events that trigger this selective expansion are not identified. This knowledge gap limits understanding of disease initiation mechanisms.

Gap type: open_question Source paper: mTORC1 Signaling in Brain Endothelial Progenitors Contributes to CCM Pathogenesis. (2024, Circulation research, PMID:38957991)

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