Gap in Seattle Hub lineage tracing: Recording Neuroimmune and Degeneration-linked Cell Histories

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Composite

83%

Novelty

85%

Mechanistic

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Druggability

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Priority

83%

Importance

81%

Tractability

80%

Market price

50%

Description

Adapt recorders to capture microglial, immune, and glial histories across neurodegeneration without triggering inflammatory artifacts. Boundary domains: neurodegeneration, neuroimmunology. Representative papers: Recording Neuroimmune and Degeneration-linked Cell Histories

Resolution criteria

Resolution requires: (1) Recorder validated in >=2 glial/immune cell types without inflammatory response (IL-6, TNF-alpha, IL-1beta <= 2x baseline); (2) Recording of >=3 distinct microglial states across neurodegeneration; (3) Cross-species validation showing >=75% conservation; (4) KG edges connecting microglial history to neurodegeneration phenotypes. Deliverable: validated recorder + glial state atlas.

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