RNA binding protein dysregulation across ALS FTD and AD

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Composite

70%

Novelty

70%

Mechanistic

—

Druggability

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Priority

86%

Importance

90%

Tractability

75%

Market price

50%

Description

RNA binding protein dysregulation across ALS FTD and AD

Evidence summary

{“hypothesis_matches”: [{“id”: “h-03e31e80”, “title”: “DAMP-Scavenging Microglial Reset”, “target_gene”: “HMGB1, S100 proteins”, “target_pathway”: null, “match_score”: 0.2, “composite_score”: 0.4622222222222222, “status”: “proposed”}, {“id”: “h-a4e259e0”, “title”: “Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain Anti-Inflammatory Communication”, “target_gene”: “CHRNA7”, “target_pathway”: “Vagal cholinergic anti-inflammatory pathway (\u03b17nAChR)”, “match_score”: 0.2, “composite_score”: 0.4601336707597654, “status”: “proposed”}, {“id”: “h-495454ef”, “title”: “Synthetic Biology Approach: Designer Mitochondrial Export Systems”, “target_gene”: “Synthetic fusion proteins”, “target_pathway”: “Synthetic biology mitochondrial export / organelle transplantation”, “match_score”: 0.2, “composite_score”: 0.3561780962214035, “status”: “proposed”}], “total_matching_hypotheses”: 3, “gap_tokens_sample”: [“AD”, “ALS”, “FTD”, “RNA”, “binding”, “dysregulation”, “protein”], “updated_at”: “2026-04-06T08:21:05.755805+00:00”}

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