Synaptic pruning by microglia in early AD

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Composite

71%

Novelty

70%

Mechanistic

—

Druggability

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Priority

88%

Importance

92%

Tractability

75%

Market price

50%

Description

Synaptic pruning by microglia in early AD

Evidence summary

{“hypothesis_matches”: [{“id”: “h-29ef94d5”, “title”: “Epigenetic Memory Reprogramming for Alzheimer’s Disease”, “target_gene”: “BDNF, CREB1, synaptic plasticity genes”, “target_pathway”: “CREB/BDNF epigenetic regulation of synaptic plasticity”, “match_score”: 0.3, “composite_score”: 0.49103059326293774, “status”: “proposed”}, {“id”: “h-a8165b3b”, “title”: “Complement-Mediated Synaptic Pruning Dysregulation”, “target_gene”: “C1QA”, “target_pathway”: “Classical complement cascade (C1q/C3/CR3 synaptic elimination)”, “match_score”: 0.24, “composite_score”: 0.39614815772140355, “status”: “proposed”}, {“id”: “h-seaad-5b3cb8ea”, “title”: “Complement C1QA Spatial Gradient in Cortical Layers”, “target_gene”: “C1QA”, “target_pathway”: “Complement Cascade / Synaptic Pruning”, “match_score”: 0.2, “composite_score”: 0.4313813923551568, “status”: “proposed”}], “total_matching_hypotheses”: 3, “gap_tokens_sample”: [“AD”, “microglia”, “pruning”, “synaptic”], “updated_at”: “2026-04-06T08:21:05.747797+00:00”}

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