Mitochondrial transfer between astrocytes and neurons

Mitochondrial transfer between astrocytes and neurons

{“hypothesis_matches”: [{“id”: “h-826df660”, “title”: “Optogenetic Control of Mitochondrial Transfer Networks”, “target_gene”: “ChR2”, “target_pathway”: “Optogenetic calcium signaling \u2192 mitochondrial fission/transfer”, “match_score”: 0.34, “composite_score”: 0.3761695528633962, “status”: “proposed”}, {“id”: “h-827a821b”, “title”: “Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Circuits”, “target_gene”: “PGC1A, SIRT1, FOXO3, mitochondrial biogenesis genes”, “target_pathway”: “PGC1\u03b1/SIRT1/FOXO3 mitochondrial biogenesis network”, “match_score”: 0.3, “composite_score”: 0.4750374279493436, “status”: “proposed”}, {“id”: “h-7dfdc5d7”, “title”: “Mitochondrial-Cytokine Axis Modulation”, “target_gene”: “Mitochondrial respiratory complexes and inflammatory cytokine receptors”, “target_pathway”: null, “match_score”: 0.27, “composite_score”: 0.4413417349914164, “status”: “proposed”}, {“id”: “h-d78123d1”, “title”: “Microglia-Derived Extracellular Vesicle Engineering for Targeted Mitochondrial Delivery”, “target_gene”: “RAB27A/LAMP2B”, “target_pathway”: “Extracellular vesicle biogenesis (ESCRT/Rab27a) / mitochondrial transfer”, “match_score”: 0.27, “composite_score”: 0.3681729702065991, “status”: “proposed”}, {“id”: “h-969bd8e0”, “title”: “Mitochondrial Transfer Pathway Enhancement”, “target_gene”: “MIRO1”, “target_pathway”: “Mitochondrial dynamics / bioenergetics”, “match_score”: 0.24, “composite_score”: 0.4281671853431352, “status”: “proposed”}, {“id”: “h-13ef5927”, “title”: “CX43 hemichannel engineering enables size-selective mitochondrial transfer”, “target_gene”: “GJA1”, “target_pathway”: “Mitochondrial dynamics / bioenergetics”, “match_score”: 0.24, “composite_score”: 0.42060217746447043, “status”: “proposed”}, {“id”: “h-6ce4884a”, “title”: “GAP43-mediated tunneling nanotube stabilization enhances neuroprotective mitochondrial transfer”, “target_gene”: “GAP43”, “target_pathway”: “Mitochondrial dynamics / bioenergetics”, “match_score”: 0.24, “composite_score”: 0.3931300467241838, “status”: “proposed”}], “total_matching_hypotheses”: 7, “gap_tokens_sample”: [“astrocytes”, “mitochondrial”, “neurons”, “transfer”], “updated_at”: “2026-04-06T08:21:05.750408+00:00”}