Perivascular spaces and glymphatic clearance failure in AD

Perivascular spaces and glymphatic clearance failure in AD

{“hypothesis_matches”: [{“id”: “h-62e56eb9”, “title”: “Glymphatic System-Enhanced Antibody Clearance Reversal”, “target_gene”: “AQP4”, “target_pathway”: “Aquaporin-4 water transport / glymphatic clearance”, “match_score”: 0.34, “composite_score”: 0.516792706254574, “status”: “proposed”}, {“id”: “h-9e9fee95”, “title”: “Circadian Glymphatic Entrainment via Targeted Orexin Receptor Modulation”, “target_gene”: “HCRTR1/HCRTR2”, “target_pathway”: “Circadian rhythm / glymphatic clearance”, “match_score”: 0.27, “composite_score”: 0.5782338701912134, “status”: “proposed”}, {“id”: “h-de579caf”, “title”: “Circadian Glymphatic Rescue Therapy (Melatonin-focused)”, “target_gene”: “MTNR1A”, “target_pathway”: “Circadian rhythm / glymphatic clearance”, “match_score”: 0.27, “composite_score”: 0.502862949061881, “status”: “proposed”}, {“id”: “h-1e28311b”, “title”: “Microglial ACE Enhancement for Amyloid Clearance”, “target_gene”: “ACE”, “target_pathway”: null, “match_score”: 0.27, “composite_score”: 0.38216700564668704, “status”: “proposed”}, {“id”: “h-var-e47f17ca3b”, “title”: “Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling for tau clearance”, “target_gene”: “SST”, “target_pathway”: “Astrocyte-glymphatic tau clearance via AQP4 and beta-frequency interneuron gating”, “match_score”: 0.27, “composite_score”: null, “status”: “proposed”}, {“id”: “h-807d7a82”, “title”: “SASP-Driven Aquaporin-4 Dysregulation”, “target_gene”: “AQP4”, “target_pathway”: “Aquaporin-4 water transport / glymphatic clearance”, “match_score”: 0.2, “composite_score”: 0.5838999488228738, “status”: “proposed”}, {“id”: “h-c8ccbee8”, “title”: “Aquaporin-4 Polarization Rescue”, “target_gene”: “AQP4”, “target_pathway”: “Aquaporin-4 water transport / glymphatic clearance”, “match_score”: 0.2, “composite_score”: 0.49396437448360236, “status”: “proposed”}, {“id”: “h-83efeed6”, “title”: “Circadian-Gated Maresin Biosynthesis Amplification”, “target_gene”: “ALOX12”, “target_pathway”: “Circadian rhythm / glymphatic clearance”, “match_score”: 0.2, “composite_score”: 0.4478022542637237, “status”: “proposed”}], “total_matching_hypotheses”: 8, “gap_tokens_sample”: [“AD”, “clearance”, “failure”, “glymphatic”, “perivascular”, “spaces”], “updated_at”: “2026-04-06T08:21:05.761317+00:00”}