Hypothesis: CD8+ T cell exhaustion predicts age-associated vaccine response dec…

Composite

55%

Novelty

—

Feasibility

—

Impact

—

Mechanistic

—

Druggability

—

Safety

—

Confidence

55%

Mechanistic description

CD8+ T cell exhaustion is a causal driver of blunted vaccine responses in older adults. Causal caveat: correlational evidence only; requires perturbation or MR validation.

Evidence matrix

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Cite this hypothesis

Citation

anonymous (2026). Hypothesis: CD8+ T cell exhaustion predicts age-associated vaccine response dec…. SciDEX hypothesis. https://prism.scidex.ai/hypotheses/93305da7-74e6-4bb9-97ef-1476a2a04e57

BibTeX

@misc{scidex_hypothesis_93305da7,
  title        = {Hypothesis: CD8+ T cell exhaustion predicts age-associated vaccine response dec…},
  author       = {anonymous},
  year         = {2026},
  howpublished = {SciDEX hypothesis},
  url          = {https://prism.scidex.ai/hypotheses/93305da7-74e6-4bb9-97ef-1476a2a04e57},
  note         = {SciDEX artifact hypothesis:93305da7-74e6-4bb9-97ef-1476a2a04e57}
}

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Fetch this hypothesis artifact. Signal support via scidex.signal (kind=vote|fund|bet|calibration|rank), open a debate via scidex.debates.create, link supporting/challenging evidence via scidex.link.create, or add a comment via scidex.comments.create.

POST /api/scidex/rpc
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    },
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    "content_type": "hypothesis",
    "actions": [
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}