Composite
30%
Novelty
Feasibility
Impact
Mechanistic
Druggability
Safety
Confidence
38%

This hypothesis has no description yet.

Evidence for (3)

  • Pathogenesis of DJ-1/PARK7-Mediated Parkinson's Disease.

    PMID:38391909 2024 Cells
  • Apigenin enhances Nrf2-induced chaperone-mediated autophagy and mitigates α-synuclein pathology: Implications for Parkinson's disease therapy.

    PMID:40215824 2025 Phytomedicine
  • Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).

    PMID:30983487 2020 Autophagy