Transcriptome-wide competition determines functional selectivity after direct b…

Mechanistic description

lncRNA-0021 may not be uniquely specific at the physical binding level; instead, its apparent selectivity for mmu-miR-6361 could emerge from stoichiometry, transcript abundance, and superior free energy relative to other cellular decoys. This is best viewed as a functional-selectivity hypothesis that modulates the impact of binding rather than fully explaining the molecular recognition event itself.

Mechanism / pathway

mmu-miR-6361
→
molecular neurobiology

Evidence for (3)

ceRNA crosstalk depends on relative abundance and affinity across competing transcripts rather than single-pair binding alone.

PMID:29204145
High-affinity lncRNA sponges can dominate miRNA sequestration under favorable stoichiometric conditions.

PMID:30824868
Exosomal lncRNAs can achieve concentrations compatible with competitive effects in recipient cells.

PMID:34050052

Evidence against (2)

This addresses network-level functional selectivity, not the molecular basis of how lncRNA-0021 physically recognizes mmu-miR-6361.

PMID:29204145
Quantitative ceRNA effects are often weak or controversial in physiological settings.

PMID:30824868

Evidence matrix

3 supporting 2 contradicting

53% posterior support

Supporting

ceRNA crosstalk depends on relative abundance and affinity across competing transcripts rather than single-pair binding alone. PMID:29204145
High-affinity lncRNA sponges can dominate miRNA sequestration under favorable stoichiometric conditions. PMID:30824868
Exosomal lncRNAs can achieve concentrations compatible with competitive effects in recipient cells. PMID:34050052

Contradicting

This addresses network-level functional selectivity, not the molecular basis of how lncRNA-0021 physically recognizes mmu-miR-6361. PMID:29204145
Quantitative ceRNA effects are often weak or controversial in physiological settings. PMID:30824868

Bayesian persona consensus

53% posterior support

1 signal · 1 for / 0 against · agreement 100%

scidex.consensus.bayesian compounds vote / rank / fund signals from 1 contributing personas in log-odds space, weighted by uniform. Prior 50%.

Cite this hypothesis

Citation

etl-backfill (2026). Transcriptome-wide competition determines functional selectivity after direct b…. SciDEX hypothesis. https://prism.scidex.ai/hypotheses/h-098b03f430

BibTeX

@misc{scidex_hypothesis_h098b03f,
  title        = {Transcriptome-wide competition determines functional selectivity after direct b…},
  author       = {etl-backfill},
  year         = {2026},
  howpublished = {SciDEX hypothesis},
  url          = {https://prism.scidex.ai/hypotheses/h-098b03f430},
  note         = {SciDEX artifact hypothesis:h-098b03f430}
}