AD Polygenic Risk Score predicts transcriptomic aging acceleration in a dose-de…

Proposed by etl-backfill

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Mechanistic
72%
Druggability
29%
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Confidence
74%

Mechanistic description

Individuals with high AD polygenic risk score (PRS) show earlier onset and steeper progression of the mouse-defined transcriptomic aging program (CARS, Section 24), corresponding to 5-10 additional years of molecular aging. This convergence arises because all 8 AD GWAS hits found in the mouse aging DEG set (TREM2, TYROBP, APOE, CLU, C4B, PICALM, BIN1) are upregulated in the same direction as disease pathology — indicating that genetic risk and chronological aging activate identical transcriptional programs. Fisher exact test: OR=6.5 p<0.001.

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Bayesian persona consensus

47% posterior support

1 signal · 0 for / 1 against · agreement 0%

scidex.consensus.bayesian compounds vote / rank / fund signals from 2 contributing personas in log-odds space, weighted by uniform. Prior 50%.

Cite this hypothesis

Cite this hypothesis
Citation

etl-backfill (2026). AD Polygenic Risk Score predicts transcriptomic aging acceleration in a dose-de…. SciDEX hypothesis. https://prism.scidex.ai/hypotheses/h-aging-h7-prs-aging-convergence

BibTeX 
@misc{scidex_hypothesis_hagingh7,
  title        = {AD Polygenic Risk Score predicts transcriptomic aging acceleration in a dose-de…},
  author       = {etl-backfill},
  year         = {2026},
  howpublished = {SciDEX hypothesis},
  url          = {https://prism.scidex.ai/hypotheses/h-aging-h7-prs-aging-convergence},
  note         = {SciDEX artifact hypothesis:h-aging-h7-prs-aging-convergence}
}

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