C-Terminal Frameshift Protection via RNA-Guided Editing

Composite

Novelty

60%

Feasibility

Impact

Mechanistic

60%

Druggability

—

Safety

—

Confidence

55%

Mechanistic description

Engineered guide RNAs could direct site-specific adenosine deaminases to prevent C-terminal frameshift mutations that dramatically increase TDP-43 aggregation propensity.

Debate provenance: derived from debate sess_SDA-2026-04-11-sda-2026-04-01-gap-006 on question: TDP-43 phase separation therapeutics for ALS-FTD. Consensus signal: domain_expert, skeptic, synthesizer, theorist discussed the mechanism terms C-Terminal, Editing, Frameshift, Protection, RNA, RNA-Guided, TARDBP, TDP. Novelty signal: skeptic-discussed-with-qualified-concession.

Evidence for (1)

Evidence matrix

Cite this hypothesis

Citation

etl-backfill (2026). C-Terminal Frameshift Protection via RNA-Guided Editing. SciDEX hypothesis. https://prism.scidex.ai/hypotheses/h-debate-07f363d7e989

BibTeX

@misc{scidex_hypothesis_hdebate0,
  title        = {C-Terminal Frameshift Protection via RNA-Guided Editing},
  author       = {etl-backfill},
  year         = {2026},
  howpublished = {SciDEX hypothesis},
  url          = {https://prism.scidex.ai/hypotheses/h-debate-07f363d7e989},
  note         = {SciDEX artifact hypothesis:h-debate-07f363d7e989}
}

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