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SpCas9 PAM-distal seed-region mismatches are the dominant predictor of off-target cleavage frequency

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2 events · started May 16, 2026, 5:31 PM · last activity 5/16/2026

May 16, 2026, 5:31 PMMay 16, 2026, 5:31 PM

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2/2
  1. Created 5/16/2026

    hypothesis.created — SpCas9 PAM-distal seed-region mismatches are the dominant predictor of off-target cleavage frequency

    anonymous
  2. Created 5/16/2026

    Hypothesis created: SpCas9 PAM-distal seed-region mismatches are the dominant predictor of off-target cleavage frequency