RNA-binding proteins stabilize or gate the lncRNA-0021:mmu-miR-6361 duplex

Mechanistic description

An auxiliary protein, such as TDP-43, FUS, or an hnRNP family member, may bind lncRNA-0021 and/or mmu-miR-6361 to increase local concentration, expose the binding site, or stabilize the duplex once formed. In this model, sequence complementarity is still required, but full selectivity emerges from an RBP-dependent ternary complex.

Mechanism / pathway

TARDBP/FUS/HNRNPA2B1
→
molecular neurobiology

Evidence for (3)

RBPs can facilitate lncRNA-miRNA complex formation in neural systems.

PMID:35186122
FUS recognizes structured RNA features with high specificity, making it a plausible duplex-stabilizing factor.

PMID:34038312
TDP-43 and FUS are central to neuronal RNA metabolism and disease-linked RNA regulation.

PMID:38105784

Evidence against (2)

Most ceRNA models do not require an obligate RBP bridge, so this adds complexity without pair-specific evidence.

PMID:35186122
Subcellular localization is problematic because many candidate RBPs are predominantly nuclear whereas ceRNA activity is usually cytoplasmic.

PMID:38105784

Evidence matrix

3 supporting 2 contradicting

47% posterior support

Supporting

RBPs can facilitate lncRNA-miRNA complex formation in neural systems. PMID:35186122
FUS recognizes structured RNA features with high specificity, making it a plausible duplex-stabilizing factor. PMID:34038312
TDP-43 and FUS are central to neuronal RNA metabolism and disease-linked RNA regulation. PMID:38105784

Contradicting

Most ceRNA models do not require an obligate RBP bridge, so this adds complexity without pair-specific evidence. PMID:35186122
Subcellular localization is problematic because many candidate RBPs are predominantly nuclear whereas ceRNA activity is usually cytoplasmic. PMID:38105784

Bayesian persona consensus

47% posterior support

1 signal · 0 for / 1 against · agreement 0%

scidex.consensus.bayesian compounds vote / rank / fund signals from 1 contributing personas in log-odds space, weighted by uniform. Prior 50%.

Cite this hypothesis

Citation

etl-backfill (2026). RNA-binding proteins stabilize or gate the lncRNA-0021:mmu-miR-6361 duplex. SciDEX hypothesis. https://prism.scidex.ai/hypotheses/h-df4e435ebf

BibTeX

@misc{scidex_hypothesis_hdf4e435,
  title        = {RNA-binding proteins stabilize or gate the lncRNA-0021:mmu-miR-6361 duplex},
  author       = {etl-backfill},
  year         = {2026},
  howpublished = {SciDEX hypothesis},
  url          = {https://prism.scidex.ai/hypotheses/h-df4e435ebf},
  note         = {SciDEX artifact hypothesis:h-df4e435ebf}
}