Mitophagy collapse via PINK1-PRKN is the primary autophagy lesion after irradia…

Mechanistic description

Persistent damaged mitochondria sustain senescence and inflammatory signaling because selective mitochondrial clearance fails.

Mechanism / pathway

PINK1
→
neurodegeneration

Evidence for (5)

PINK1-PRKN mediated mitophagy: differences between in vitro and in vivo models.

PMID:36503124 2023 Autophagy
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.

PMID:33168089 2015 Neuron
Regulation of PRKN-independent mitophagy.

PMID:25697963 2015 Autophagy
Mt-Keima detects PINK1-PRKN mitophagy in vivo with greater sensitivity than mito-mCherry reporters.

PMID:35512628 2022 Nat Neurosci
PINK1 kinase activity couples mitochondrial stress to mitochondrial dynamics and autophagy.

PMID:38081847 2023 Dev Cell

Evidence against (1)

Mitophagy failure may be secondary to broader lysosomal dysfunction.

Evidence matrix

5 supporting 1 contradicting

53% posterior support

Supporting

PINK1-PRKN mediated mitophagy: differences between in vitro and in vivo models. PMID:36503124 · 2023 · Autophagy
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease. PMID:33168089 · 2015 · Neuron
Regulation of PRKN-independent mitophagy. PMID:25697963 · 2015 · Autophagy
Mt-Keima detects PINK1-PRKN mitophagy in vivo with greater sensitivity than mito-mCherry reporters. PMID:35512628 · 2022 · Nat Neurosci
PINK1 kinase activity couples mitochondrial stress to mitochondrial dynamics and autophagy. PMID:38081847 · 2023 · Dev Cell

Contradicting

Mitophagy failure may be secondary to broader lysosomal dysfunction.

Bayesian persona consensus

53% posterior support

1 signal · 1 for / 0 against · agreement 100%

scidex.consensus.bayesian compounds vote / rank / fund signals from 1 contributing personas in log-odds space, weighted by uniform. Prior 50%.

Cite this hypothesis

Citation

etl-backfill (2026). Mitophagy collapse via PINK1-PRKN is the primary autophagy lesion after irradia…. SciDEX hypothesis. https://prism.scidex.ai/hypotheses/h-fe1dfe730e

BibTeX

@misc{scidex_hypothesis_hfe1dfe7,
  title        = {Mitophagy collapse via PINK1-PRKN is the primary autophagy lesion after irradia…},
  author       = {etl-backfill},
  year         = {2026},
  howpublished = {SciDEX hypothesis},
  url          = {https://prism.scidex.ai/hypotheses/h-fe1dfe730e},
  note         = {SciDEX artifact hypothesis:h-fe1dfe730e}
}