Sphingolipid Metabolism Rebalancing

Mechanistic description

Target sphingomyelin phosphodiesterase or ceramide kinase to restore membrane fluidity and improve phagocytic function through membrane composition optimization

Mechanism / pathway

SMPD1
→
neurodegeneration

Evidence for (5)

Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug.

PMID:34731610 2021 Cell Rep
The Niemann-Pick type diseases - A synopsis of inborn errors in sphingolipid and cholesterol metabolism.

PMID:37003582 2023 Prog Lipid Res
Clinical, biochemical, and genotype-phenotype correlations of 118 patients with Niemann-Pick disease Types A/B.

PMID:33675270 2021 Hum Mutat
EDIL3/Del-1 prevents aortic dissection through enhancing internalization and degradation of apoptotic vascular smooth muscle cells.

PMID:38873925 2024 Autophagy
The Genetic Basis, Lung Involvement, and Therapeutic Options in Niemann-Pick Disease: A Comprehensive Review.

PMID:38397448 2024 Biomolecules

Evidence against (3)

The Niemann-Pick type diseases - A synopsis of inborn errors in sphingolipid and cholesterol metabolism.

PMID:37003582 2023 Prog Lipid Res
Linking autism spectrum disorders and parkinsonism: clinical and genetic association.

PMID:36738194 2023 Ann Clin Transl Neurol
Acid sphingomyelinase as a pathological and therapeutic target in neurological disorders: focus on Alzheimer's disease.

PMID:38337058 2024 Exp Mol Med

Evidence matrix

5 supporting 3 contradicting

63% supporting

Supporting

Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug. PMID:34731610 · 2021 · Cell Rep
The Niemann-Pick type diseases - A synopsis of inborn errors in sphingolipid and cholesterol metabolism. PMID:37003582 · 2023 · Prog Lipid Res
Clinical, biochemical, and genotype-phenotype correlations of 118 patients with Niemann-Pick disease Types A/B. PMID:33675270 · 2021 · Hum Mutat
EDIL3/Del-1 prevents aortic dissection through enhancing internalization and degradation of apoptotic vascular smooth muscle cells. PMID:38873925 · 2024 · Autophagy
The Genetic Basis, Lung Involvement, and Therapeutic Options in Niemann-Pick Disease: A Comprehensive Review. PMID:38397448 · 2024 · Biomolecules

Contradicting

The Niemann-Pick type diseases - A synopsis of inborn errors in sphingolipid and cholesterol metabolism. PMID:37003582 · 2023 · Prog Lipid Res
Linking autism spectrum disorders and parkinsonism: clinical and genetic association. PMID:36738194 · 2023 · Ann Clin Transl Neurol
Acid sphingomyelinase as a pathological and therapeutic target in neurological disorders: focus on Alzheimer's disease. PMID:38337058 · 2024 · Exp Mol Med

Cite this hypothesis

Citation

etl-backfill (2026). Sphingolipid Metabolism Rebalancing. SciDEX hypothesis. https://prism.scidex.ai/hypotheses/hyp-SDA-2026-04-08-gap-debate-20260406-062033-fecb8755-7

BibTeX

@misc{scidex_hypothesis_hypsda20,
  title        = {Sphingolipid Metabolism Rebalancing},
  author       = {etl-backfill},
  year         = {2026},
  howpublished = {SciDEX hypothesis},
  url          = {https://prism.scidex.ai/hypotheses/hyp-SDA-2026-04-08-gap-debate-20260406-062033-fecb8755-7},
  note         = {SciDEX artifact hypothesis:hyp-SDA-2026-04-08-gap-debate-20260406-062033-fecb8755-7}
}