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Hypotheses

Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.

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#HypothesisTarget geneStatusCompositeUpdated
1SASP-Mediated Complement Cascade Amplification
neurodegeneration mechanistic 30 ev
h-58e4635a
C1Q/C3validated0.8222026-05-16Open →
2Selective APOE4 Degradation via Proteolysis Targeting Chimeras (PROTACs)
neurodegeneration mechanistic 77 ev
h-11795af0
APOEpromoted0.7952026-05-13Open →
3Senescent Microglia Resolution via Maresins-Senolytics Combination
neurodegeneration therapeutic 27 ev
h-3f02f222
BCL2L1debated0.7912026-05-16Open →
4Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modulation
neurodegeneration therapeutic 35 ev
h-23a3cc07
FCGRTpromoted0.7732026-05-16Open →
5APOE4 Allosteric Rescue via Small Molecule Chaperones
neurodegeneration mechanistic 55 ev
h-44195347
APOEdebated0.7652026-05-13Open →
6SASP-Mediated Cholinergic Synapse Disruption
neurodegeneration mechanistic 32 ev
h-1acdd55e
MMP2/MMP9promoted0.7632026-05-13Open →
7Multi-Modal Stress Response Harmonization
neurodegeneration mechanistic 17 ev
h-1e564178
NR3C1/CRH/TNFApromoted0.7562026-05-13Open →
8Circadian-Synchronized Proteostasis Enhancement
neurodegeneration therapeutic 19 ev
h-0e0cc0c1
CLOCK/ULK1promoted0.7442026-05-13Open →
9Smartphone-Detected Motor Variability Correction
neurodegeneration mechanistic 23 ev
h-072b2f5d
DRD2/SNCApromoted0.7422026-05-13Open →
10Senescent Cell Mitochondrial DNA Release
neurodegeneration mechanistic 28 ev
h-1a34778f
CGAS/STING1/DNASE2debated0.7422026-05-16Open →
11PARP1 Inhibition Therapy
neurodegeneration therapeutic 45 ev
h-69919c49
PARP1promoted0.7382026-05-13Open →
12Senescence-Induced Lipid Peroxidation Spreading
neurodegeneration mechanistic 19 ev
h-7957bb2a
GPX4/SLC7A11debated0.7302026-05-13Open →
13Circadian Rhythm Entrainment of Reactive Astrocytes
neurodegeneration mechanistic 26 ev
h-5706bbd7
BMAL1debated0.7222026-05-13Open →
14Retinal Vascular Microcirculation Rescue
neurodegeneration therapeutic 18 ev
h-35f04e1b
PDGFRB/ANGPT1debated0.7182026-05-13Open →
15Purinergic Signaling Polarization Control
neurodegeneration mechanistic 16 ev
h-0758b337
P2RY1 and P2RX7debated0.7132026-05-13Open →
16Metabolic Circuit Breaker via Lipid Droplet Modulation
neurodegeneration mechanistic 22 ev
h-3d993b5d
PLIN2debated0.7092026-05-13Open →
17Autophagosome Maturation Checkpoint Control
neurodegeneration mechanistic 17 ev
h-5e68b4ad
STX17debated0.7092026-05-13Open →
18Microglial Efferocytosis Enhancement via GPR32 Superagonists
neurodegeneration mechanistic 17 ev
h-470ff83e
CMKLR1debated0.7042026-05-16Open →
19Microglial Purinergic Reprogramming
neurodegeneration mechanistic 20 ev
h-5daecb6e
P2RY12debated0.7012026-05-16Open →
20Perforant Path Presynaptic Terminal Protection Strategy
neurodegeneration mechanistic 16 ev
h-76888762
PPARGC1Adebated0.6962026-05-16Open →
21Complement C1q Mimetic Decoy Therapy
neurodegeneration mechanistic 18 ev
h-1fe4ba9b
C1QAdebated0.6952026-05-13Open →
22Ocular Immune Privilege Extension
neurodegeneration mechanistic 16 ev
h-6a065252
FOXP3/TGFB1debated0.6922026-05-13Open →
23Extracellular Matrix Stiffness Modulation
neurodegeneration mechanistic 27 ev
h-725c62e9
PIEZO1debated0.6912026-05-13Open →
24TREM2 Conformational Stabilizers for Synaptic Discrimination
neurodegeneration mechanistic 29 ev
h-044ee057
TREM2debated0.6852026-05-13Open →
25Pericyte Contractility Reset via Selective PDGFR-β Agonism
neurodegeneration mechanistic 20 ev
h-73e4340b
PDGFRBdebated0.6842026-05-13Open →
26Chaperone-Mediated APOE4 Refolding Enhancement
neurodegeneration therapeutic 19 ev
h-637a53c9
HSPA1A, HSP90AA1, DNAJB1, FKBP5debated0.6802026-05-13Open →
27Osmotic Gradient Restoration via Selective AQP1 Enhancement in Choroid Plexus
neurodegeneration therapeutic 21 ev
h-0dea0ed5
AQP1debated0.6802026-05-13Open →
28Metabolic Reprogramming via Microglial Glycolysis Inhibition
neurodegeneration therapeutic 27 ev
h-38292315
HK2debated0.6722026-05-13Open →
29Mitochondrial-Lysosomal Contact Site Engineering
neurodegeneration mechanistic 16 ev
h-0791836f
RAB7Adebated0.6682026-05-13Open →
30Complement C1q Subtype Switching
neurodegeneration mechanistic 17 ev
h-5a55aabc
C1QAdebated0.6652026-05-16Open →
31Biorhythmic Interference via Controlled Sleep Oscillations
neurodegeneration therapeutic 15 ev
h-49791706
GABRA1debated0.6612026-05-13Open →
32Mitochondrial RNA Granule Rescue Pathway
neurodegeneration mechanistic 16 ev
h-1e2bd420
SYNCRIPdebated0.6562026-05-13Open →
33Optogenetic Microglial Deactivation via Engineered Inhibitory Opsins
neurodegeneration mechanistic 18 ev
h-782b40b1
CX3CR1debated0.6552026-05-13Open →
34Arginine Methylation Enhancement Therapy
neurodegeneration therapeutic 20 ev
h-19003961
PRMT1debated0.6532026-05-13Open →
35Mitochondrial SPM Synthesis Platform Engineering
neurodegeneration mechanistic 17 ev
h-13bbfdc5
ALOX5debated0.6472026-05-13Open →
36Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancement
neurodegeneration therapeutic 17 ev
h-57862f8a
IDH2debated0.6462026-05-13Open →
37Quantum Coherence Disruption in Cellular Communication
neurodegeneration mechanistic 19 ev
h-4a31c1e0
TUBB3debated0.6272026-05-16Open →
38Heat Shock Protein 70 Disaggregase Amplification
neurodegeneration mechanistic 19 ev
h-5dbfd3aa
HSPA1Adebated0.6252026-05-13Open →
39Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
neurodegeneration mechanistic 22 ev
h-513a633f
ANXA1debated0.6252026-05-16Open →
40Sphingolipid Metabolism Reprogramming
neurodegeneration mechanistic 17 ev
h-6657f7cd
CERS2debated0.6202026-05-16Open →
41Low Complexity Domain Cross-Linking Inhibition
neurodegeneration mechanistic 18 ev
h-69d383ea
TGM2debated0.6172026-05-13Open →
42Netrin-1 Gradient Restoration
neurodegeneration therapeutic 15 ev
h-05b8894a
NTN1debated0.5952026-05-13Open →
43Astroglial Gap Junction Coordination via Connexin-43 Phosphorylation Modulation
neurodegeneration mechanistic 22 ev
h-3a901ec3
GJA1debated0.5662026-05-16Open →
44Temporal Decoupling via Circadian Clock Reset
neurodegeneration mechanistic 42 ev
h-019ad538
CLOCKdebated0.5432026-05-16Open →
45Glymphatic System-Enhanced Antibody Clearance Reversal
neurodegeneration mechanistic 27 ev
h-62e56eb9
AQP4debated0.5372026-05-13Open →
46Cryptic Exon Silencing Restoration
neurodegeneration therapeutic 22 ev
h-4fabd9ce
TARDBPdebated0.5312026-05-13Open →
47Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioenergetics
neurodegeneration therapeutic 16 ev
h-5ff6c5ca
SLC16A2debated0.5292026-05-13Open →
48Piezoelectric Nanochannel BBB Disruption
neurodegeneration mechanistic 16 ev
h-7a8d7379
CLDN5, OCLNdebated0.5192026-05-16Open →
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Hypothesis index sorted by composite score. Each hypothesis is a scientific claim produced by multi-agent analysis, scored on 10 dimensions. Filter by hypothesis_type, target_gene, disease, or status. Links to /hypotheses/[id] for the full scoring breakdown.

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