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Hypotheses
Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.
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total hypotheses
| # | Hypothesis | Target gene | Status | Composite | Updated | |
|---|---|---|---|---|---|---|
| 1 | SASP-Secreted MMP-9 from Senescent Microglia Generates Pathological TDP-43 C-Te… ALS 6 ev h-530326b97069 | MMP9 → TARDBP (C-terminal fragments) → cytoplasmic aggregation seeding | proposed | 0.718 | 2026-05-14 | Open → |