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Hypotheses
Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.
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total hypotheses
| # | Hypothesis | Target gene | Status | Composite | Updated | |
|---|---|---|---|---|---|---|
| 1 | SASP-Secreted MMP-9 from Senescent Microglia Disrupts TDP-43 Nuclear Retention… ALS 6 ev h-var-a3cfa5bb63 | MMP9 → nuclear import machinery (KPNA1, NUP proteins, LMNA) → TARDBP cytoplasmic mislocalization | proposed | 0.511 | 2026-05-16 | Open → |