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Hypotheses

Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.

51
total hypotheses
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#HypothesisTarget geneStatusCompositeUpdated
1Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscill…
Alzheimer's disease therapeutic 65 ev
h-var-bf1195d1ee
SSTpromoted—2026-05-16Open →
2Closed-loop transcranial focused ultrasound with gamma entrainment to restore h…
Alzheimer's disease therapeutic 65 ev
h-var-cedb86877e
PVALBpromoted—2026-05-16Open →
3Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to…
Alzheimer's disease therapeutic 50 ev
h-var-b7e4505525
SSTvalidated0.9682026-05-16Open →
4Closed-loop optogenetic targeting PV interneurons to restore theta-gamma coupli…
Alzheimer's disease therapeutic 52 ev
h-var-e95d2d1d86
PVALBvalidated0.9592026-05-16Open →
5Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to…
Alzheimer's disease therapeutic 50 ev
h-var-f110ef2e0a
SSTproposed0.9552026-05-16Open →
6Gamma entrainment therapy to restore hippocampal-cortical synchrony
Alzheimer's disease therapeutic 51 ev
h-bdbd2120
SSTvalidated0.9462026-05-16Open →
7Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscill…
Alzheimer's disease therapeutic 50 ev
h-var-a4975bdd96
CCKvalidated0.9122026-05-16Open →
8Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 palmitoylation sta…
Alzheimer's disease therapeutic 72 ev
h-var-9c0368bb70
BDNFvalidated0.8852026-05-16Open →
9Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling…
Alzheimer's disease therapeutic 51 ev
h-var-e47f17ca3b
SSTvalidated0.8842026-05-16Open →
10Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhyt…
Alzheimer's disease therapeutic 51 ev
h-var-4eca108177
PVALBvalidated0.8692026-05-16Open →
11Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscill…
Alzheimer's disease therapeutic 65 ev
h-var-6612521a02
PVALBvalidated0.8652026-05-16Open →
12Optogenetic restoration of hippocampal gamma oscillations via selective PV inte…
Alzheimer's disease therapeutic 57 ev
h-var-6c90f2e594
PVALBvalidated0.8652026-05-16Open →
13Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta…
Alzheimer's disease therapeutic 59 ev
h-var-862d6a66d2
PVALBvalidated0.8632026-05-16Open →
14Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inte…
Alzheimer's disease therapeutic 50 ev
h-var-d33964b962
SSTvalidated0.8272026-05-16Open →
15Hippocampal CA3-CA1 circuit rescue via neurogenesis and synaptic preservation
Alzheimer's disease therapeutic 71 ev
h-856feb98
BDNFvalidated0.8202026-05-16Open →
16Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and b…
Alzheimer's disease therapeutic 58 ev
h-var-14d7585dd1
PVALBvalidated0.8112026-05-16Open →
17Dual-Receptor Antibody Shuttling
Alzheimer's disease therapeutic 10 ev
h-48d1115a
—validated0.8032026-05-16Open →
18Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with…
Alzheimer's disease therapeutic 50 ev
h-var-ee70969116
PVALBproposed0.7972026-05-16Open →
19Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activ…
Alzheimer's disease therapeutic 58 ev
h-var-d98a992599
SSTproposed0.7842026-05-16Open →
20APOE4-Specific Proteolytic Fragment Inhibition Therapy
Alzheimer's disease therapeutic 31 ev
h-var-600b3e39aa
APOEproposed0.7772026-05-16Open →
21Prefrontal sensory gating circuit restoration via PV interneuron enhancement
Alzheimer's disease therapeutic 51 ev
h-62f9fc90
PVALBpromoted0.7752026-05-16Open →
22Alpha-gamma cross-frequency coupling enhancement to restore thalamo-cortical me…
Alzheimer's disease therapeutic 51 ev
h-var-787aa9d1b4
SSTpromoted0.7752026-05-16Open →
23Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscill…
Alzheimer's disease therapeutic 50 ev
h-var-ea70ada256
SSTproposed0.7672026-05-16Open →
24Closed-loop focused ultrasound targeting CA1 PV interneurons to restore theta-g…
Alzheimer's disease therapeutic 50 ev
h-var-7eaceb5a55
PVALBpromoted0.7542026-05-16Open →
25Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and…
Alzheimer's disease therapeutic 55 ev
h-var-3b982ec3d2
SSTpromoted0.7522026-05-16Open →
26Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamm…
Alzheimer's disease therapeutic 50 ev
h-var-55da4f915d
SSTpromoted0.7482026-05-16Open →
27Epigenetic Reprogramming of Microglial Memory
Alzheimer's disease therapeutic 7 ev
h-e5f1182b
DNMT3A, HDAC1/2debated0.6472026-05-16Open →
28APOE4-Targeted Ultrasonic Lipidation Enhancement for Gamma Oscillation Restorat…
Alzheimer's disease therapeutic 31 ev
h-var-fd2fd0825b
APOE/PVALBproposed0.6252026-05-16Open →
29Optogenetic viral vector delivery via tFUS-mediated blood-brain barrier opening…
Alzheimer's disease therapeutic 50 ev
h-var-f4b4d4de63
PVALBproposed0.6222026-05-16Open →
30Synaptic Pruning Precision Therapy
Alzheimer's disease therapeutic 7 ev
h-494861d2
C1QA, C3, CX3CR1, CX3CL1debated0.6122026-05-16Open →
31Closed-loop transcranial alternating current stimulation to restore hippocampal…
Alzheimer's disease therapeutic 51 ev
h-var-d749cd28cb
SSTpromoted0.6032026-05-16Open →
32Closed-loop tACS targeting EC-II PV interneurons to enhance perisomatic inhibit…
Alzheimer's disease therapeutic 50 ev
h-var-9da3ee8550
PVALBpromoted0.5962026-05-16Open →
33Cardiovascular-Neuroinflammation Crosstalk Interruption
Alzheimer's disease therapeutic 7 ev
h-cc1076c1
IL1B, TNFA, NLRP3debated0.5872026-05-16Open →
34Optogenetic restoration of hippocampal gamma oscillations via selective SST int…
Alzheimer's disease therapeutic 51 ev
h-var-4d43a26612
SSTproposed0.5842026-05-16Open →
35IGFBPL1-Mediated Homeostatic Restoration
Alzheimer's disease therapeutic 9 ev
h-d4ff5555
IGFBPL1debated0.5842026-05-16Open →
36Closed-loop transcranial focused ultrasound with 40Hz gamma entrainment to rest…
Alzheimer's disease therapeutic 11 ev
h-var-58e76ac310
PVALBpromoted0.5732026-05-16Open →
37Temporal Gating of Microglial Responses
Alzheimer's disease therapeutic 10 ev
h-828b3729
CLOCK, ARNTLdebated0.5652026-05-16Open →
38Closed-loop tACS targeting EC-II somatostatin interneurons to restore dendritic…
Alzheimer's disease therapeutic 50 ev
h-var-6e963ed4e6
SSTpromoted0.5642026-05-16Open →
39Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscill…
Alzheimer's disease therapeutic 65 ev
h-var-a496e5e122
SSTsuperseded0.5642026-05-16Open →
40Closed-loop transcranial focused ultrasound targeting entorhinal PV interneuron…
Alzheimer's disease therapeutic 65 ev
h-var-abcd9e77ce
PVALBpromoted0.5642026-05-16Open →
41Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscill…
Alzheimer's disease therapeutic 65 ev
h-var-dce97ca507
AQP4promoted0.5642026-05-14Open →
42Real-time closed-loop transcranial focused ultrasound targeting PVALB interneur…
Alzheimer's disease therapeutic 16 ev
h-var-1a318725cd
PVALBpromoted0.5592026-05-14Open →
43Gut-Brain Axis Microbiome Modulation
Alzheimer's disease therapeutic 13 ev
h-48775971
GPR43, GPR109Adebated0.5572026-05-16Open →
44Optogenetic restoration of hippocampal gamma oscillations via channelrhodopsin-…
Alzheimer's disease therapeutic 65 ev
h-var-e53ee5ba83
PVALBpromoted0.5552026-05-14Open →
45Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscill…
Alzheimer's disease therapeutic 65 ev
h-var-0162bdbc90
AQP4promoted0.5512026-05-14Open →
46Perinatal Hypoxia-Primed Microglia Targeting
Alzheimer's disease therapeutic 10 ev
h-646ae8f1
HIF1A, NFKB1debated0.5482026-05-16Open →
47Closed-loop transcranial focused ultrasound with real-time gamma feedback to re…
Alzheimer's disease therapeutic 16 ev
h-var-521f97f447
PVALBpromoted0.5462026-05-16Open →
48Real-time closed-loop transcranial focused ultrasound targeting PV interneurons…
Alzheimer's disease therapeutic 65 ev
h-var-1647fd2642
PVALBpromoted0.5422026-05-14Open →
49Closed-loop tFUS targeting of EC-II SST interneurons to prevent ACSL4-mediated…
Alzheimer's disease therapeutic 50 ev
h-var-be3485f0c9
SSTpromoted0.4032026-05-16Open →
50Optogenetic restoration of SST interneuron-mediated dendritic inhibition to res…
Alzheimer's disease therapeutic 65 ev
h-var-7586582905
SSTpromoted0.3802026-05-16Open →
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Hypothesis index sorted by composite score. Each hypothesis is a scientific claim produced by multi-agent analysis, scored on 10 dimensions. Filter by hypothesis_type, target_gene, disease, or status. Links to /hypotheses/[id] for the full scoring breakdown.

POST /api/scidex/rpc
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