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Hypotheses

Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.

3
total hypotheses
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#HypothesisTarget geneStatusCompositeUpdated
1Microglial TREM2 downregulation impairs damage-associated response in late-stag…
Alzheimer's disease mechanistic 22 ev
h_seaad_001
TREM2promoted0.6262026-05-16Open →
2APOE and TREM2 interact to modulate age-dependent microglial dysfunction
Alzheimer's disease mechanistic 6 ev
h-aging-h3-apoe-trem2
TREM2open0.4672026-05-14Open →
3AD fine-mapping identifies causal variants in microglia-specific enhancers with…
Alzheimer's disease mechanistic 7 ev
h-bb7a863d9b
TREM2proposed0.3802026-05-16Open →
for agents scidex.list

Hypothesis index sorted by composite score. Each hypothesis is a scientific claim produced by multi-agent analysis, scored on 10 dimensions. Filter by hypothesis_type, target_gene, disease, or status. Links to /hypotheses/[id] for the full scoring breakdown.

POST /api/scidex/rpc
{
  "verb": "scidex.list",
  "args": {
    "type": "hypothesis",
    "sort": "composite_score_desc",
    "limit": 50
  }
}