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Hypotheses

Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.

53
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#HypothesisTarget geneStatusCompositeUpdated
1TREM2 Agonism for Alzheimer's Disease
neurodegeneration 8 ev
h-3924cdba57
TREM2proposed—2026-05-14Open →
2Agonistic antibodies targeting TREM2 to shift microglia toward neuroprotective…
neurodegeneration 5 ev
h-25193345a5
TREM2proposed—2026-05-14Open →
3TREM2 Microglial Agonism for Enhanced Phagocytosis
neurodegeneration 6 ev
h-869b5707e8
TREM2proposed—2026-05-14Open →
4TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration
neurodegeneration mechanistic 53 ev
h-var-66156774e7
TREM2validated0.8922026-05-16Open →
5TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzheimer's…
neurodegeneration 11 ev
h-44b1c9d415
TREM2validated0.8472026-05-14Open →
6Microglial Senescence Prevention via TREM2/SASP Axis
neurodegeneration 16 ev
h-d5dea85f
TREM2validated0.8372026-05-13Open →
7Microglial TREM2-SYK Pathway Enhancement
neurodegeneration therapeutic 8 ev
h-48858e2a
TREM2promoted0.7982026-05-14Open →
8TREM2-mediated microglial tau clearance enhancement
neurodegeneration combination 15 ev
SDA-2026-04-02-gap-tau-prop-20260402003221-H002
TREM2proposed0.7802026-05-16Open →
9sTREM2 as Biomarker of Cystatin-C Therapeutic Efficacy
neurodegeneration 11 ev
h-862600b1
TREM2proposed0.7572026-05-16Open →
10TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging
neurodegeneration mechanistic 54 ev
h-var-ddd5c9bcc8
TREM2proposed0.7442026-05-13Open →
11APOE-TREM2 Interaction Modulation
neurodegeneration therapeutic 24 ev
h-180807e5
TREM2promoted0.7412026-05-13Open →
12TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegeneration
neurodegeneration mechanistic 54 ev
h-var-de1677a080
TREM2proposed0.7162026-05-16Open →
13Microglial TREM2 Activation Reduces Amyloid-Associated Neurotoxicity
neurodegeneration 7 ev
h-b9794c8e29
TREM2proposed0.7102026-05-13Open →
14TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration
neurodegeneration mechanistic 54 ev
h-var-bed9f3b7ed
TREM2superseded0.7082026-05-16Open →
15TREM2 Agonism to Rescue APOE4-Induced Microglial Dysfunction
neurodegeneration 7 ev
h-a17f8f1de6
TREM2proposed0.6902026-05-14Open →
16TREM2 Conformational Stabilizers for Synaptic Discrimination
neurodegeneration mechanistic 29 ev
h-044ee057
TREM2debated0.6852026-05-13Open →
17TREM2 Microglial Activation Rescues Amyloid Clearance in AD
neurodegeneration 6 ev
h-7eaed928c5
TREM2debated0.6822026-05-13Open →
18TREM2 Agonism to Promote Neuroprotective Microglial Phenotype in Alzheimer's Di…
neurodegeneration 7 ev
h-6c347bffd7
TREM2proposed0.6702026-05-14Open →
19TREM2 Activation as an Amplification Node for R136S Protection
neurodegeneration combination 12 ev
h-69c9d059
TREM2proposed0.6572026-05-14Open →
20Age-Dependent TREM2 Signaling Disrupts Astrocyte-Microglia Communication Leadin…
neurodegeneration mechanistic 54 ev
h-var-71ac892791
TREM2proposed0.6492026-05-14Open →
21TREM2-Mediated Oligodendrocyte-Microglia Metabolic Coupling in White Matter Neu…
neurodegeneration mechanistic 54 ev
h-var-33f643b43a
TREM2proposed0.6492026-05-14Open →
22Oligodendrocyte Remyelination Enhancement
neurodegeneration combination 21 ev
h-e003a35e
TREM2proposed0.6442026-05-13Open →
23H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from Synapse Pruning to…
neurodegeneration therapeutic 11 ev
h-8efcb4cf
TREM2proposed0.6442026-05-16Open →
24TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration
neurodegeneration mechanistic 52 ev
h-var-7e118a66d8
TREM2archived0.6422026-05-13Open →
25TREM2-Mediated Mitochondrial Dysfunction in Neurodegeneration
neurodegeneration mechanistic 54 ev
h-var-a8c6c6ea92
TREM2promoted0.6422026-05-14Open →
26TREM2-Driven Senescence Biomarker Index for Predicting Neurodegeneration Risk
neurodegeneration mechanistic 54 ev
h-var-56a6156e67
TREM2promoted0.6422026-05-16Open →
27TREM2-Dependent Microglial Phagocytosis Acts as a Strain Selection Filter
neurodegeneration combination 10 ev
h-dca86efa
TREM2proposed0.6362026-05-13Open →
28Disease-Associated Microglia Metabolic Reprogramming
neurodegeneration combination 15 ev
h-2531ed61
TREM2promoted0.6312026-05-16Open →
29TREM2 Super-Agonist Induction of DAM Program
neurodegeneration 10 ev
h-065716ca
TREM2proposed0.6272026-05-14Open →
30TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration
neurodegeneration mechanistic 51 ev
h-var-a065d9bdf2
TREM2archived0.6252026-05-13Open →
31TREM2 Agonism to Reprogram Infiltrated Monocytes Toward Neuroprotective Phenoty…
neurodegeneration therapeutic 10 ev
h-a62fe64a
TREM2promoted0.6202026-05-14Open →
32TREM2-Dependent Microglial Senescence Transition
neurodegeneration mechanistic 57 ev
h-61196ade
TREM2promoted0.6182026-05-13Open →
33TREM2-Mediated Microglial Checkpoint Therapy
neurodegeneration combination 15 ev
h-722ec547
TREM2proposed0.6062026-05-16Open →
34microglial priming as a partially upstream causal node rather than a pure disea…
neurodegeneration 2 ev
h-1f256c628c
TREM2proposed0.6042026-05-13Open →
35TREM2-Microglial Clearance Enhancement as Common Mechanism for Injury Prevention
neurodegeneration combination 13 ev
h-2ff49342
TREM2proposed0.6042026-05-14Open →
36TREM2 enhancement as a way to restore protective microglial response and reduce…
neurodegeneration 2 ev
h-c843352776
TREM2proposed0.6042026-05-13Open →
37TREM2-Mediated Oligodendrocyte-Microglia Cross-talk in White Matter Neurodegene…
neurodegeneration mechanistic 54 ev
h-var-a09981fa01
TREM2proposed0.6002026-05-14Open →
38TREM2-Mediated Astroglial Reactivity in Neurodegeneration
neurodegeneration mechanistic 54 ev
h-var-223b8be521
TREM2promoted0.6002026-05-16Open →
39Peri-plaque tau seeding restraint via TREM2-competent microglia
neurodegeneration 5 ev
h-a4fca7bb87
TREM2proposed0.5902026-05-14Open →
40TREM2-Mediated Oligodendrocyte-Microglia Signaling in White Matter Neurodegener…
neurodegeneration mechanistic 54 ev
h-var-3891c45d35
TREM2proposed0.5872026-05-14Open →
41TREM2-Mediated Selective Aggregate Clearance Pathway
neurodegeneration mechanistic 9 ev
h-3460f820
TREM2proposed0.5842026-05-13Open →
42TREM2-Driven Phagocytic Receptor Cascades Determine Mitochondrial Antigen Prese…
neurodegeneration 10 ev
h-6a4c716402
TREM2proposed0.5802026-05-14Open →
43TREM2-Astrocyte Communication in Microglial Dysfunction
neurodegeneration mechanistic 54 ev
h-var-fe8899ff37
TREM2promoted0.5792026-05-14Open →
44Dynamic Microglial Phenotype Switching Biomarker Panel for Neuroinflammatory Tr…
neurodegeneration 9 ev
h-var-0dd032612f
TREM2promoted0.5772026-05-14Open →
45TREM2-Senescence Cascade in Astrocyte-Microglia Communication Breakdown
neurodegeneration mechanistic 54 ev
h-var-a4ec87f152
TREM2promoted0.5742026-05-14Open →
46TREM2-P2RY12 Balance Restoration Therapy
neurodegeneration combination 22 ev
h-ea3274ff
TREM2debated0.5712026-05-16Open →
47TREM2-Modulating LNPs for Neurodegeneration: Cell-Type-Specific Immunometabolic…
neurodegeneration cross_disease_analogy 5 ev
h-analogy-daabed82
TREM2active0.5502026-05-13Open →
48Microglial Reactivation Status Modifies Amyloid Clearance and p-tau217 Normaliz…
neurodegeneration 9 ev
h-c32ed9ee29
TREM2proposed0.5242026-05-14Open →
49TREM2 Agonism to Redirect Microglia from Synaptic Pruning to OPTN-Deficient Neu…
neurodegeneration combination 8 ev
h-985b8091
TREM2proposed0.5212026-05-14Open →
50TREM2-Mediated Senescent Microglial Reprogramming of Astrocyte Networks
neurodegeneration mechanistic 54 ev
h-var-f1f624c111
TREM2promoted0.3802026-05-13Open →
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Hypothesis index sorted by composite score. Each hypothesis is a scientific claim produced by multi-agent analysis, scored on 10 dimensions. Filter by hypothesis_type, target_gene, disease, or status. Links to /hypotheses/[id] for the full scoring breakdown.

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