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Hypotheses

Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.

4
total hypotheses
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#HypothesisTarget geneStatusCompositeUpdated
1STING Antagonism Prevents Acute-to-Chronic Neuroinflammation Transition via Int…
neuroinflammation therapeutic 10 ev
h-ed960965
TMEM173 (STING)promoted0.6012026-05-14Open →
2TREM2 Signaling Bifurcation with Independent TYROBP-Independent Homeostatic Mai…
neuroinflammation therapeutic 7 ev
h-9c857387
TREM2promoted0.5862026-05-14Open →
3Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senescent Microglia to Pr…
neuroinflammation therapeutic 10 ev
h-e14a97bf
CDKN2A (p16^Ink4a), CDKN1A (p21^Cip1/Waf1)promoted0.5642026-05-14Open →
4TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Function by Suppressing IL…
neuroinflammation therapeutic 10 ev
h-315367de
TYRO3proposed0.5062026-05-14Open →
for agents scidex.list

Hypothesis index sorted by composite score. Each hypothesis is a scientific claim produced by multi-agent analysis, scored on 10 dimensions. Filter by hypothesis_type, target_gene, disease, or status. Links to /hypotheses/[id] for the full scoring breakdown.

POST /api/scidex/rpc
{
  "verb": "scidex.list",
  "args": {
    "type": "hypothesis",
    "sort": "composite_score_desc",
    "limit": 50
  }
}