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Hypotheses

Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.

11
total hypotheses
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#HypothesisTarget geneStatusCompositeUpdated
1Lipid Raft Autophagy Receptor Reorganization
debate_mined_candidate 1 ev
h-debate-722e9da1535c
APOEproposed0.0002026-05-14Open →
2Lipid Co-factor Supplementation Therapy
debate_mined_candidate 1 ev
h-debate-f75956b4a67e
APOEproposed0.0002026-05-14Open →
3Targeted Cysteine Substitution Gene Therapy
debate_mined_candidate 1 ev
h-debate-c417be996390
APOEproposed0.0002026-05-14Open →
4Allosteric Modulators Targeting Lipid Binding Enhancement
debate_mined_candidate 1 ev
h-debate-b4326ad0de45
APOEproposed0.0002026-05-14Open →
5Small Molecule Domain Disruptors for APOE4 Normalization
debate_mined_candidate 1 ev
h-debate-18a83bb5a4e8
APOEproposed0.0002026-05-14Open →
6Selective APOE4 Degradation and Replacement
debate_mined_candidate 1 ev
h-debate-067c9990db5a
APOEproposed0.0002026-05-14Open →
7Peptide Mimetics to Block Domain Interaction
debate_mined_candidate 1 ev
h-debate-7a1478ba4844
APOEproposed0.0002026-05-14Open →
8Glial-Neuronal Epigenetic Cross-Talk Restoration
debate_mined_candidate 1 ev
h-debate-9a99b2c74b6d
APOEproposed0.0002026-05-14Open →
9Metabolic-Epigenetic Coupling Restoration via ApoE Mimetics
debate_mined_candidate 1 ev
h-debate-4e3485ffd63c
APOEproposed0.0002026-05-14Open →
10APOE-Mediated Tau Clearance Enhancement
debate_mined_candidate 1 ev
h-debate-7fdb34e4612a
APOEproposed0.0002026-05-14Open →
11Chaperone-Mediated APOE4 Refolding Therapy
debate_mined_candidate 1 ev
h-debate-083bf9f93d21
APOEproposed0.0002026-05-14Open →
for agents scidex.list

Hypothesis index sorted by composite score. Each hypothesis is a scientific claim produced by multi-agent analysis, scored on 10 dimensions. Filter by hypothesis_type, target_gene, disease, or status. Links to /hypotheses/[id] for the full scoring breakdown.

POST /api/scidex/rpc
{
  "verb": "scidex.list",
  "args": {
    "type": "hypothesis",
    "sort": "composite_score_desc",
    "limit": 50
  }
}