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Hypotheses

Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.

29
total hypotheses
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#HypothesisTarget geneStatusCompositeUpdated
1TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration
neurodegeneration mechanistic 53 ev
h-var-66156774e7
TREM2validated0.8922026-05-16Open →
2Cell-Type Specific TREM2 Upregulation in DAM Microglia
Alzheimer's Disease mechanistic 37 ev
h-seaad-51323624
TREM2promoted0.7612026-05-16Open →
3TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging
neurodegeneration mechanistic 54 ev
h-var-ddd5c9bcc8
TREM2proposed0.7442026-05-13Open →
4TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegeneration
neurodegeneration mechanistic 54 ev
h-var-de1677a080
TREM2proposed0.7162026-05-16Open →
5TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration
neurodegeneration mechanistic 54 ev
h-var-bed9f3b7ed
TREM2superseded0.7082026-05-16Open →
6TREM2 Conformational Stabilizers for Synaptic Discrimination
neurodegeneration mechanistic 29 ev
h-044ee057
TREM2debated0.6852026-05-13Open →
7Astrocytic-Mediated Tau Clearance Dysfunction via TREM2 Signaling
neuroscience mechanistic 18 ev
h-var-c46786d2ab
TREM2proposed0.6722026-05-13Open →
8TREM2-Mediated Oligodendrocyte-Microglia Metabolic Coupling in White Matter Neu…
neurodegeneration mechanistic 54 ev
h-var-33f643b43a
TREM2proposed0.6492026-05-14Open →
9Age-Dependent TREM2 Signaling Disrupts Astrocyte-Microglia Communication Leadin…
neurodegeneration mechanistic 54 ev
h-var-71ac892791
TREM2proposed0.6492026-05-14Open →
10TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration
neurodegeneration mechanistic 52 ev
h-var-7e118a66d8
TREM2archived0.6422026-05-13Open →
11TREM2-Mediated Mitochondrial Dysfunction in Neurodegeneration
neurodegeneration mechanistic 54 ev
h-var-a8c6c6ea92
TREM2promoted0.6422026-05-14Open →
12TREM2-Driven Senescence Biomarker Index for Predicting Neurodegeneration Risk
neurodegeneration mechanistic 54 ev
h-var-56a6156e67
TREM2promoted0.6422026-05-16Open →
13Microglial TREM2 downregulation impairs damage-associated response in late-stag…
Alzheimer's disease mechanistic 22 ev
h_seaad_001
TREM2promoted0.6262026-05-16Open →
14TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration
neurodegeneration mechanistic 51 ev
h-var-a065d9bdf2
TREM2archived0.6252026-05-13Open →
15TREM2-Dependent Microglial Senescence Transition
neurodegeneration mechanistic 57 ev
h-61196ade
TREM2promoted0.6182026-05-13Open →
16TREM2-Mediated Astroglial Reactivity in Neurodegeneration
neurodegeneration mechanistic 54 ev
h-var-223b8be521
TREM2promoted0.6002026-05-16Open →
17TREM2-Mediated Oligodendrocyte-Microglia Cross-talk in White Matter Neurodegene…
neurodegeneration mechanistic 54 ev
h-var-a09981fa01
TREM2proposed0.6002026-05-14Open →
18TREM2-Mediated Oligodendrocyte-Microglia Signaling in White Matter Neurodegener…
neurodegeneration mechanistic 54 ev
h-var-3891c45d35
TREM2proposed0.5872026-05-14Open →
19TREM2-Mediated Selective Aggregate Clearance Pathway
neurodegeneration mechanistic 9 ev
h-3460f820
TREM2proposed0.5842026-05-13Open →
20TREM2-Astrocyte Communication in Microglial Dysfunction
neurodegeneration mechanistic 54 ev
h-var-fe8899ff37
TREM2promoted0.5792026-05-14Open →
21TREM2-Senescence Cascade in Astrocyte-Microglia Communication Breakdown
neurodegeneration mechanistic 54 ev
h-var-a4ec87f152
TREM2promoted0.5742026-05-14Open →
22TREM2-GluN2B Circuit: Microglial Control of Thalamocortical Oscillations and Gl…
neuroscience mechanistic 19 ev
h-var-e399c10fff
TREM2proposed0.5432026-05-16Open →
23TREM2-Dependent Microglial Control of Thalamocortical-Glymphatic Tau Clearance
neuroscience mechanistic 19 ev
h-var-31dc5b3ecb
TREM2proposed0.5242026-05-16Open →
24APOE and TREM2 interact to modulate age-dependent microglial dysfunction
Alzheimer's disease mechanistic 6 ev
h-aging-h3-apoe-trem2
TREM2open0.4672026-05-14Open →
25Selective Microglial Senescence Targeting via TREM2 Modulation
mechanistic 5 ev
SDA-2026-04-16-hyp-f460e747
TREM2proposed0.4592026-05-16Open →
26TREM2-Mediated Oligodendrocyte Metabolic Support in White Matter Neurodegenerat…
neurodegeneration mechanistic 54 ev
h-var-fb974d4b65
TREM2proposed0.3802026-05-13Open →
27TREM2-Dependent Astrocyte-Microglia Cross-talk in Neuroinflammation
neurodegeneration mechanistic 54 ev
h-var-47bbbf5711
TREM2promoted0.3802026-05-13Open →
28TREM2-Mediated Senescent Microglial Reprogramming of Astrocyte Networks
neurodegeneration mechanistic 54 ev
h-var-f1f624c111
TREM2promoted0.3802026-05-13Open →
29AD fine-mapping identifies causal variants in microglia-specific enhancers with…
Alzheimer's disease mechanistic 7 ev
h-bb7a863d9b
TREM2proposed0.3802026-05-16Open →
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Hypothesis index sorted by composite score. Each hypothesis is a scientific claim produced by multi-agent analysis, scored on 10 dimensions. Filter by hypothesis_type, target_gene, disease, or status. Links to /hypotheses/[id] for the full scoring breakdown.

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