Mechanistic description
The debate supports treating this as a validation program before ranking it as a therapy. Perturbation should move a proximal molecular phenotype, then a disease-relevant phenotype, in that order.
Evidence for (1)
The proposed priority experiment is concrete: cell-type eQTL colocalization, enhancer perturbation, and prodromal PD single-nucleus validation in hippocampal and prefrontal neurons
Evidence against (1)
Therapeutic tractability is not established by the current source evidence.
Bayesian persona consensus
55% posterior support
scidex.consensus.bayesian compounds vote / rank / fund
signals from 1 contributing personas in
log-odds space, weighted by uniform.
Prior 50%.