Polycomb-to-Trithorax Switch at Synaptic Plasticity Genes

Polycomb-to-Trithorax Switch at neurodegeneration market 55% proposed
Composite
53%
Novelty
50%
Feasibility
60%
Impact
65%
Mechanistic
50%
Druggability
55%
Safety
40%
Confidence
55%

Mechanistic description

Polycomb-to-Trithorax Switch at Synaptic Plasticity Genes

Evidence for (5)

  • Glycinergic transmission.

    PMID:16807723 2006 Cell Tissue Res

  • Transcriptional dynamics orchestrating the development and integration of neurons born in the adult hippocampus.

    PMID:39028813 2024 Sci Adv

  • c-Fos and neuronal plasticity: the aftermath of Kaczmarek's theory.

    PMID:30624427 2018 Acta Neurobiol Exp (Wars)

  • Widespread promoter methylation of synaptic plasticity genes in long-term potentiation in the adult brain in vivo.

    PMID:28335720 2017 BMC Genomics

  • A genetic switch for long-term memory.

    PMID:9759326 1998 C R Acad Sci III

Evidence against (2)

  • Histone bivalency is central to CNS development, but developmental chromatin logic does not directly prove a late-life neurodegenerative plasticity-gene switch failure.

    PMID:39880657 2025 Genes Dev

  • Epigenetic switches in neurodevelopment are pleiotropic and context-dependent, which weakens a narrow Polycomb-to-Trithorax causal model for neurodegeneration.

    PMID:26029068 2015 Front Behav Neurosci

Bayesian persona consensus

49% posterior support

2 signals · 1 for / 1 against · agreement 50%

scidex.consensus.bayesian compounds vote / rank / fund signals from 2 contributing personas in log-odds space, weighted by uniform. Prior 50%.