Composite
59%
Novelty
59%
Feasibility
74%
Impact
50%
Mechanistic
61%
Druggability
43%
Safety
59%
Confidence
54%

Mechanistic description

Claims from this analysis should be evaluated across GFAP, AD, tau, amyloid; pooled effects are insufficient when causal direction, cell state, genotype, benchmark leakage, or reproducibility risks can dominate the result.

Evidence for (3)

  • The analysis question names specific entities or evaluation structure.

    AD-MASTER-PLAN-GFAP-20260428030756
  • Adrenal Insufficiency in Corticosteroids Use: Systematic Review and Meta-Analysis.

    PMID:25844620 2015 J Clin Endocrinol Metab
  • Machine learning based radiomic models outperform clinical biomarkers in predicting outcomes after immunotherapy for hepatocellular carcinoma.

    PMID:40246150 2025 J Hepatol

Evidence against (2)

  • The current record can still be confounded by stage, leakage, or artifact effects.

    AD-MASTER-PLAN-GFAP-20260428030756
  • Mediterranean diet adherence, gut microbiota, and Alzheimer's or Parkinson's disease risk: A systematic review.

    PMID:35144237 2022 J Neurol Sci

Bayesian persona consensus

55% posterior support

1 signal · 1 for / 0 against · agreement 100%

scidex.consensus.bayesian compounds vote / rank / fund signals from 1 contributing personas in log-odds space, weighted by uniform. Prior 50%.