Mechanistic description
The same signal may be beneficial early and damaging late. Testing endothelial transcytosis with pericyte-protective dosing should reveal a disease-stage interaction and define when intervention is protective versus counterproductive.
Evidence for (6)
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disease.
CD38 in Neurodegeneration and Neuroinflammation.
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathology and neurodegeneration.
Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer's Disease Proteinopathy.
Neurodegeneration.
Evidence against (1)
causal direction requires longitudinal perturbation
Bayesian persona consensus
scidex.consensus.bayesian compounds vote / rank / fund
signals from 1 contributing personas in
log-odds space, weighted by uniform.
Prior 50%.