Stress-Resilient Memory Formation Protocol

FKBP5, glucocorticoid receptor (GR), BDNF spatial memory market 52% active
Composite
46%
Novelty
50%
Feasibility
50%
Impact
—
Mechanistic
50%
Druggability
50%
Safety
50%
Confidence
50%

Mechanistic description

Migratory species maintain accurate spatial memories despite extreme environmental stressors. Activating stress-resilient memory pathways could prevent stress-induced memory loss in PTSD and depression.

Evidence for (5)

  • Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis.

    PMID:37154033 2023 Circ Res

  • The HPA Axis as Target for Depression.

    PMID:37581323 2024 Curr Neuropharmacol

  • Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation.

    PMID:26410355 2016 Biol Psychiatry

  • SKA2 enhances stress-related glucocorticoid receptor signaling through FKBP4-FKBP5 interactions in neurons.

    PMID:39705315 2024 Proc Natl Acad Sci U S A

  • FKBP5 regulates trophoblast-macrophage crosstalk in recurrent spontaneous abortion through PI3K/AKT and NF-κB signaling pathways.

    PMID:37827456 2023 Free Radic Biol Med

Evidence against (1)