Circadian-Spatial Memory Coupling for Navigation Disorders

CLOCK, BMAL1, hippocampal place cells spatial memory market 52% active
Composite
46%
Novelty
50%
Feasibility
50%
Impact
—
Mechanistic
50%
Druggability
50%
Safety
50%
Confidence
50%

Mechanistic description

Migration routes are maintained through coupling of circadian rhythms with spatial memory networks. Restoring disrupted circadian-hippocampal connectivity could treat spatial disorientation in neurodegenerative diseases.

Evidence for (5)

  • BMAL1-TRIM28 represses transposable elements independently of CLOCK in pluripotent cells.

    PMID:40931039 2025 Nat Commun

  • Haploinsufficiency of a Circadian Clock Gene Bmal1 (Arntl or Mop3) Causes Brain-Wide mTOR Hyperactivation and Autism-like Behavioral Phenotypes in Mice.

    PMID:35682995 2022 Int J Mol Sci

  • Rare variants in BMAL1 are associated with a neurodevelopmental syndrome.

    PMID:40720646 2025 Proc Natl Acad Sci U S A

  • Circadian rhythms in the absence of the clock gene Bmal1.

    PMID:32054765 2020 Science

  • Defining the Independence of the Liver Circadian Clock.

    PMID:31150621 2019 Cell

Evidence against (1)