Social Memory Network Enhancement Therapy

Oxytocin receptor (OXTR), mirror neuron networks spatial memory market 52% active
Composite
46%
Novelty
50%
Feasibility
50%
Impact
—
Mechanistic
50%
Druggability
50%
Safety
50%
Confidence
50%

Mechanistic description

Migration routes are transmitted socially across generations. Social memory network stimulation therapy could treat memory disorders by enhancing interpersonal transmission and reinforcement of memories.

Evidence for (5)

  • The Oxytocin Receptor: From Intracellular Signaling to Behavior.

    PMID:29897293 2018 Physiol Rev

  • A dedicated hypothalamic oxytocin circuit controls aversive social learning.

    PMID:38267576 2024 Nature

  • Oxytocin Receptor Regulates the Hippo/YAP Axis to Drive Hepatocarcinogenesis.

    PMID:40742309 2025 Cancer Res

  • Distinct oxytocin signaling pathways synergistically mediate rescue-like behavior in mice.

    PMID:40267134 2025 Proc Natl Acad Sci U S A

  • Oxytocin receptor is not required for social attachment in prairie voles.

    PMID:36708707 2023 Neuron

Evidence against (3)

  • Pituitary crosstalk with bone, adipose tissue and brain.

    PMID:37715028 2023 Nat Rev Endocrinol

  • Vagal neurocircuitry and its influence on gastric motility.

    PMID:27251213 2016 Nat Rev Gastroenterol Hepatol

  • The stress system in the human brain in depression and neurodegeneration.

    PMID:15996533 2005 Ageing Res Rev