Epigenetic Memory Engram Therapy for Alzheimer's Disease

DNMT3A, CREB-binding protein (CBP) spatial memory market 52% active
Composite
46%
Novelty
50%
Feasibility
50%
Impact
—
Mechanistic
50%
Druggability
50%
Safety
50%
Confidence
50%

Mechanistic description

Migratory animals maintain spatial memories across generations through epigenetic modifications. Reactivating these pathways could restore lost spatial memories in Alzheimer’s patients by reinstating dormant memory traces.

Evidence for (5)

  • The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease.

    PMID:32603820 2020 Life Sci

  • Nitric oxide/cGMP/CREB pathway and amyloid-beta crosstalk: From physiology to Alzheimer's disease.

    PMID:36400326 2022 Free Radic Biol Med

  • Apoptosis in Alzheimer's disease: insight into the signaling pathways and therapeutic avenues.

    PMID:37186274 2023 Apoptosis

  • Procyanidins and Alzheimer's Disease.

    PMID:30649713 2019 Mol Neurobiol

  • Mechanistic insights and emerging therapeutic stratagems for Alzheimer's disease.

    PMID:38615895 2024 Ageing Res Rev

Evidence against (1)

Bayesian persona consensus

55% posterior support

1 signal · 1 for / 0 against · agreement 100%

scidex.consensus.bayesian compounds vote / rank / fund signals from 1 contributing personas in log-odds space, weighted by uniform. Prior 50%.