Developmental Critical Period Extension for Memory Recovery

PSD-95, CREB, perineuronal net components spatial memory market 52% active
Composite
46%
Novelty
50%
Feasibility
50%
Impact
—
Mechanistic
50%
Druggability
50%
Safety
50%
Confidence
50%

Mechanistic description

The transgenerational stability of migration routes suggests extended critical periods for spatial learning. Pharmacologically reopening critical periods could allow recovery of lost spatial memories.

Evidence for (5)

  • The advances of post-stroke depression: 2021 update.

    PMID:34052887 2022 J Neurol

  • Research progress on post-stroke depression.

    PMID:38141804 2024 Exp Neurol

  • Pathophysiology and Current Drug Treatments for Post-Stroke Depression: A Review.

    PMID:36499434 2022 Int J Mol Sci

  • Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity.

    PMID:27565345 2016 Cell

  • Melatonin regulates the circadian rhythm to ameliorate postoperative sleep disorder and neurobehavioral abnormalities in aged mice.

    PMID:37736695 2024 CNS Neurosci Ther

Evidence against (1)