Membrane Curvature-Responsive Cell-Penetrating Nanobodies

MAPT molecular biology market 52% active
Composite
46%
Novelty
50%
Feasibility
50%
Impact
—
Mechanistic
50%
Druggability
50%
Safety
50%
Confidence
50%

Mechanistic description

Nanobodies conjugated to curvature-sensitive cell-penetrating peptides that preferentially penetrate highly curved or deformed membranes could achieve selective entry into tau-containing vesicles.

Evidence for (5)

  • MAPT mutations, tauopathy, and mechanisms of neurodegeneration.

    PMID:30742061 2019 Lab Invest

  • Tau-targeting antisense oligonucleotide MAPT(Rx) in mild Alzheimer's disease: a phase 1b, randomized, placebo-controlled trial.

    PMID:37095250 2023 Nat Med

  • Interactions between Microtubule-Associated Protein Tau (MAPT) and Small Molecules.

    PMID:27940599 2017 Cold Spring Harb Perspect Med

  • ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.

    PMID:34314701 2021 Cell

  • The six brain-specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromes.

    PMID:38556838 2024 Alzheimers Dement

Evidence against (1)