SciDEX hypotheses
Hypothesis corpus
Scored, debated, and tradable. Each hypothesis carries composite, novelty, impact, mechanistic, druggability, and safety scores — plus a live market price when a collider is open.
4,512
hypotheses
Showing neuroscience hypotheses, sorted by Composite score.
Thalamocortical Synchrony Restoration via NMDA Modulation
GRIN2B neuroscience 77%Thalamocortical circuit integrity differentiates normal aging from mild cognitive impairment, with decreased neural complexity and increased synchronization being hallmarks of dysfunction
h-cd60e2ecDifferential Interneuron Optogenetic Restoration Therapy
PVALB/SST neuroscience 60%Optogenetic activation of SST and PV interneurons in Aβ-oligomer injected mice selectively restored theta and gamma oscillations respectively, with SST interneurons specifically restoring theta peak p…
h-f8316acf