SciDEX hypotheses
Hypothesis corpus
Scored, debated, and tradable. Each hypothesis carries composite, novelty, impact, mechanistic, druggability, and safety scores — plus a live market price when a collider is open.
5,531
hypotheses
Showing alzheimer hypotheses, sorted by Composite score.
Hippocampal-Cortical Transcriptomic Divergence Reveals Accelerated Neurodegeneration-Like Signatures
CDKN2A alzheimer 52%p16INK4a+ senescent cell accumulation in hippocampus supports region-specific aging transcriptomics.
h-aging-hippo-cortex-divergenceMyelin Breakdown-Amyloid Interaction Amplifies Cortical Aging-Neurodegeneration Overlap
MBP alzheimer 51%58% posterior · 2 signalsEpigenetic drift at MBP/PLP1 myelination genes supported by DNA methylation changes in aging mouse brain.
h-aging-myelin-amyloidELF2-Mediated OPC Epigenetic Drift Drives Region-Dependent Myelin Dysfunction
ELF2 alzheimer 51%53% posterior · 1 signalProgressive DNA methylation drift in aging mouse brain supports epigenetic mechanism for OPC dysfunction.
h-aging-opc-elf2