Hypothesis corpus
Scored, debated, and tradable. Each hypothesis carries composite, novelty, impact, mechanistic, druggability, and safety scores — plus a live market price when a collider is open.
Showing alzheimers hypotheses, sorted by Composite score.
Alpha-theta entrainment therapy to enhance default mode network coherence
SST alzheimers40 Hz gamma entrainment reduces amyloid and tau pathology in 5XFAD and tau P301S mice
h-var-08841db86aClosed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via SST interneuron disinhibition cascades in Alzheimer's disease
SST alzheimers40 Hz gamma entrainment reduces amyloid and tau pathology in 5XFAD and tau P301S mice
h-var-bf1195d1eeClosed-loop transcranial focused ultrasound with gamma entrainment to restore hippocampal-cortical synchrony via PV interneuron mechanostimulation
PVALB alzheimers40 Hz gamma entrainment reduces amyloid and tau pathology in 5XFAD and tau P301S mice
h-var-cedb86877eClosed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocampal gamma oscillations via upstream perforant path gating in Alzheimer's disease
SST alzheimers 97%40 Hz gamma entrainment reduces amyloid and tau pathology in 5XFAD and tau P301S mice
h-var-b7e4505525Closed-loop optogenetic targeting PV interneurons to restore theta-gamma coupling and prevent amyloid-induced synaptic dysfunction in AD
PVALB alzheimers 96%40 Hz gamma entrainment reduces amyloid and tau pathology in 5XFAD and tau P301S mice
h-var-e95d2d1d86Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to prevent tau propagation and restore entorhinal-hippocampal gamma synchrony in early Alzheimer's disease
SST alzheimers 96%40 Hz gamma entrainment reduces amyloid and tau pathology in 5XFAD and tau P301S mice
h-var-f110ef2e0aGamma entrainment therapy to restore hippocampal-cortical synchrony
SST alzheimers 95%40 Hz gamma entrainment reduces amyloid and tau pathology in 5XFAD and tau P301S mice
h-bdbd2120Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via cholecystokinin interneuron neuromodulation in Alzheimer's disease
CCK alzheimers 91%40 Hz gamma entrainment reduces amyloid and tau pathology in 5XFAD and tau P301S mice
h-var-a4975bdd96ACSL4-Driven Ferroptotic Priming in Disease-Associated Microglia
ACSL4 alzheimers 89%ACSL4 shapes cellular lipid composition to trigger ferroptosis through PUFA-PE enrichment
h-seaad-v4-26ba859bHippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 palmitoylation stabilization
BDNF alzheimers 89%Adult hippocampal neurogenesis is impaired in AD
h-var-9c0368bb70Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling for tau clearance
SST alzheimers 88%40 Hz gamma entrainment reduces amyloid and tau pathology in 5XFAD and tau P301S mice
h-var-e47f17ca3bClosed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhythmogenesis and block tau AIS disruption in AD
PVALB alzheimers 87%40 Hz gamma entrainment reduces amyloid and tau pathology in 5XFAD and tau P301S mice
h-var-4eca108177Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via direct PV interneuron recruitment in Alzheimer's disease
PVALB alzheimers 87%40 Hz gamma entrainment reduces amyloid and tau pathology in 5XFAD and tau P301S mice
h-var-6612521a02Optogenetic restoration of hippocampal gamma oscillations via selective PV interneuron activation using implantable LED arrays in Alzheimer's disease
PVALB alzheimers 87%40 Hz gamma entrainment reduces amyloid and tau pathology in 5XFAD and tau P301S mice
h-var-6c90f2e594Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-gamma coupling and prevent tau seeding in AD
PVALB alzheimers 86%40 Hz gamma entrainment reduces amyloid and tau pathology in 5XFAD and tau P301S mice
h-var-862d6a66d2Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocampal-prefrontal synchrony in early AD
SST alzheimers 83%40 Hz gamma entrainment reduces amyloid and tau pathology in 5XFAD and tau P301S mice
h-var-d33964b962Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via glymphatic enhancement and amyloid clearance from PV interneurons in Alzheimer's disease
PVALB alzheimers 83%40 Hz gamma entrainment reduces amyloid and tau pathology in 5XFAD and tau P301S mice
h-var-9e8fc8fd3dGamma entrainment repairs cross-regional phase-amplitude coupling via CA1 Schaffer collateral plasticity
GRIN2A/GRIN2B (NR2A/NR2B NMDA receptors), CAMK2A alzheimers 83%Sleep-dependent gamma entrainment restores hippocampal-cortical coordination
h-620a7b5b79Hippocampal CA3-CA1 circuit rescue via neurogenesis and synaptic preservation
BDNF alzheimers 82%Adult hippocampal neurogenesis is impaired in AD
h-856feb98Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and block tau propagation via perforant path in AD
PVALB alzheimers 81%40 Hz gamma entrainment reduces amyloid and tau pathology in 5XFAD and tau P301S mice
h-var-14d7585dd1Dual-Receptor Antibody Shuttling
alzheimers 80%Ketoboronate as a Minimal Covalent-Reversible Tag for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins.
h-48d1115a40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Selectively Eliminate Disease-Associated Microglia
ACSL4 alzheimers 80%ACSL4 shapes cellular lipid composition to trigger ferroptosis through PUFA-PE enrichment
h-var-261452bfb4ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degeneration in Alzheimer's Disease
ACSL4 alzheimers 80%ACSL4 shapes cellular lipid composition to trigger ferroptosis through PUFA-PE enrichment
h-var-22c38d11cdClosed-loop transcranial focused ultrasound targeting CA1 PV interneurons with real-time gamma feedback to prevent tau propagation and restore hippocampal-prefrontal synchrony in Alzheimer's disease
PVALB alzheimers 80%40 Hz gamma entrainment reduces amyloid and tau pathology in 5XFAD and tau P301S mice
h-var-ee70969116