Hypothesis corpus
Scored, debated, and tradable. Each hypothesis carries composite, novelty, impact, mechanistic, druggability, and safety scores — plus a live market price when a collider is open.
Showing biomarkers hypotheses, sorted by Composite score.
Integrated Multi-Analyte CSF Panel Combining YKL-40, sTREM2, and Neurogranin
CHI3L1/TREM2/NRGN biomarkers 81%53% posterior · 1 signalCSF YKL-40 and sTREM2 show distinct temporal patterns in AD progression
h-dffb42d9deCSF YKL-40 as a Priming-Specific Chitinase Marker
CHI3L1/YKL-40 biomarkers 72%53% posterior · 1 signalElevated CSF YKL-40 in pre-symptomatic familial AD
h-25ec762b3fCSF Soluble TREM2 Fragment Ratio as Priming State Indicator
TREM2/ADAM10/17 biomarkers 69%53% posterior · 1 signalCSF sTREM2 increases in early symptomatic AD
h-b490c14bf6P2X7R PET Imaging for NLRP3 Inflammasome-Associated Priming
P2RX7/NLRP3 biomarkers 56%P2X7R deletion or blockade prevents microglial priming in mouse models
h-763d9c478eTSPO PET Kinetic Modeling for Priming State Discrimination
TSPO biomarkers 52%53% posterior · 1 signalTSPO PET elevation in AD, MS, and neurodegenerative conditions
h-2a31d5df00Blood Monocyte Epigenetic Signature as Surrogate for Microglial Priming
Epigenetic landscape (TLR4, NLRP3, IL1B regulatory regions) biomarkers 51%53% posterior · 1 signalEpigenetic signatures in blood predict neurodegenerative disease progression
h-15f088c56fCX3CR1 PET with Nano-bodies for Microglial Surveillance State Mapping
CX3CR1 biomarkers 48%47% posterior · 1 signalCX3CR1 haploinsufficiency accelerates neurodegeneration in mouse models
h-5f3db142c9Plasma TREM2 Ectodomain Glycosylation Pattern as Therapeutic Response Predictor
TREM2/ST6GAL1/MGAT5 biomarkers 43%47% posterior · 1 signalCSF sTREM2 increases in early symptomatic AD
h-var-e8e7961a54Dynamic Plasma Exosome-Derived Multi-Analyte Panel Combining YKL-40, sTREM2, and Neurogranin
CHI3L1/TREM2/NRGN biomarkers 39%47% posterior · 1 signalCSF YKL-40 and sTREM2 show distinct temporal patterns in AD progression
h-var-b625142c91CSF TREM2 Fragment Ratio Integrated with Neuroinflammatory Cascade Markers
TREM2 biomarkers 38%47% posterior · 1 signalCSF YKL-40 and sTREM2 show distinct temporal patterns in AD progression
h-var-03da47e875Plasma TREM2 Ectodomain Glycosylation Patterns as Microglial Senescence Biomarker
TREM2/ST6GAL1/MGAT5 biomarkers 38%51% posterior · 2 signalsCSF sTREM2 increases in early symptomatic AD
h-var-4ae5ef95faDynamic Blood-Based Exosome Panel for Real-Time Neuroinflammatory State Monitoring Using YKL-40, sTREM2, and Neurogranin
CHI3L1/TREM2/NRGN biomarkers 38%47% posterior · 1 signalCSF YKL-40 and sTREM2 show distinct temporal patterns in AD progression
h-var-92ba62855aSite-Specific TREM2 Fragment Analysis Within Multi-Analyte CSF Panel for Microglial Priming Detection
TREM2 biomarkers 37%47% posterior · 1 signalCSF YKL-40 and sTREM2 show distinct temporal patterns in AD progression
h-var-5f0a621982