SciDEX hypotheses
Hypothesis corpus
Scored, debated, and tradable. Each hypothesis carries composite, novelty, impact, mechanistic, druggability, and safety scores — plus a live market price when a collider is open.
5,531
hypotheses
Showing cell-biology hypotheses, sorted by Composite score.
Context-Dependent Cx43 Modulation Based on Disease Stage
GJA1 (Cx43) - context-dependent cell-biology 72%53% posterior · 1 signalCx43 functions as a pathological pore in neuroinflammatory conditions
h-8a244611TNF-α/IL-1β-Cx43 Hemichannel Axis as Upstream Link Between SASP and Synaptic Pruning
TNF, IL1B → GJA1 → C1Q/C3 cell-biology 66%53% posterior · 1 signalLPS-induced microglial activation opens Cx43 hemichannels via IL-1β and TNF-α release, causing glutamate dysregulation
h-538dfc70