Hypothesis corpus
Scored, debated, and tradable. Each hypothesis carries composite, novelty, impact, mechanistic, druggability, and safety scores — plus a live market price when a collider is open.
Showing molecular-biology hypotheses, sorted by Composite score.
p16^INK4a-CCF Axis as Senolytic Timing Biomarker
CDKN2A, CGAS, STING1 molecular-biology 81%CCF formation precedes SASP and is detectable before SA-β-gal positivity
h-70bc216f06p21^Cip1 Phospho-State as Autophagy Responsiveness Predictor
CDKN1A, CDK4, CDK6, ATM, PPP1CA molecular-biology 77%53% posterior · 1 signalCDK4/6 inhibition senolytics via p21-dependent mechanism
h-94ae1e45a0APOE4-driven lysosome-to-ER cholesterol transport failure reduces ER-accessible cholesterol and releases SCAP-SREBP2 from ER retention
NPC1 molecular-biology 74%APOE4 glia show lysosomal cholesterol accumulation and altered cholesterol homeostasis consistent with compartmental misrouting rather than simple cholesterol deficiency.
h-1b47a73770APOE4 hypolipidation and ABCA1 mistrafficking impair cholesterol efflux and secondarily reduce ER sterol sensing
ABCA1 molecular-biology 69%53% posterior · 1 signalAPOE4 is associated with ABCA1 mistrafficking, impaired recycling, and reduced cholesterol efflux in astrocytic systems.
h-bf7edcbc78mTORC1 Reactivation as Autophagy-Senescence Divergence Point Marker
MTOR, RPTOR, RPS6KB1, TSC1, TSC2 molecular-biology 68%53% posterior · 1 signalmTORC1 hyperactivity drives senescence in human fibroblasts via autophagy blockade
h-82100428d0GDF15-GFRAL Axis as Systemic Autophagy-Senescence Integrator
GDF15, GFRAL, NTRK2 molecular-biology 66%53% posterior · 1 signalGDF15 is a biomarker of autophagy-lysosome dysfunction in aging
h-8ef10f60b8Glial-Autophagy-Senescence Coupling Defines CNS Therapeutic Windows
TFEB, MAPK14, MAPKAPK2, IL6, CXCL1 molecular-biology 61%53% posterior · 1 signalAstrocyte senescence drives neurodegeneration via SASP in ALS models
h-b47073b186MALAT1 Three-Way Junction as a Druggable Target for Structure-Selective ASOs
MALAT1 molecular-biology 59%MALAT1 triple helix domain conserved across mammals
h-01eb4f1d71Upstream restoration of glial lipid efflux and apoE lipidation will outperform direct SREBP2 inhibition therapeutically
LXR molecular-biology 58%53% posterior · 1 signalLXR-ABCA1 pathway activation improves glial lipid phenotypes and apoE biology in APOE4-relevant systems.
h-4e823a876aMultivalent Scaffold Theory: Rif1 SAF Domain Array as High-Valency Condensate Core
RIF1 molecular-biology 58%Rif1 forms oligomers through SAF domain-mediated interactions
h-c0c52aec62ITGAM/CD11b direct binding explains microglial phagocytosis blockade
ITGAM molecular-biology 58%C1qa-/- and Itgam-/- mice show impaired postinjury debris clearance, supporting a functional C1q-CR3 axis.
h-b0defed1Conserved G-Quadruplex Forming Potential in HOTAIR Defines Therapeutic Window
HOTAIR molecular-biology 57%HOTAIR 5' domain structure is partially conserved
h-06d5f49673Sticker-Spacer Phase Behavior Determines Recruitment Hierarchy
53BP1/TP53BP1 molecular-biology 56%53% posterior · 1 signalSticker-spacer model accurately predicts protein partitioning into condensates
h-15d40f8710