Hypothesis corpus
Scored, debated, and tradable. Each hypothesis carries composite, novelty, impact, mechanistic, druggability, and safety scores — plus a live market price when a collider is open.
Showing neuroinflammation hypotheses, sorted by Composite score.
IL-6 Trans-Signaling Blockade at the Oligodendrocyte-Microglia Interface
IL6R, IL6 neuroinflammation 83%Central IL-6 trans-signaling inhibition reduces neuroinflammation and facilitates recovery from LPS-induced sickness behavior
h-2dbf5f1fSTING Antagonists as ALS Therapeutics: Drug Repurposing
STING (TMEM173) neuroinflammation 82%53% posterior · 1 signalH-151 covalently inhibits STING Cys91 and blocks IFN-β production in vivo
h-6fe30c39bcPDE4 Inhibition as Inflammatory Reset for PD Oligodendrocytes
PDE4A, PDE4B, PDE4D neuroinflammation 78%53% posterior · 1 signalPDE4 inhibition promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination
h-67914e81TREM2 Crosstalk and Synergistic Activation of Phagocytic Transcriptome
TREM2/DAP12 (TYROBP) neuroinflammation 76%TREM2 is master regulator of microglial phagocytosis
h-adfcd3f146Temporal SPP1 Inhibition During Critical Windows
SPP1 neuroinflammation 75%53% posterior · 1 signalIdentification of a tumour immune barrier in the HCC microenvironment that determines the efficacy of immunotherapy.
h-655c7f33Peripheral Monocyte/Macrophage Infiltration Mimicking Microglial Loss
CCR2 neuroinflammation 74%53% posterior · 1 signalCirrhosis increases MMP-9 and BBB permeability
h-f9dca82e35Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determines AQP4 Tolerance Fate
AHR, IL10, TNFRSF13B, TIGIT, FOXP3 neuroinflammation 74%Microbiota-derived metabolites suppress arthritis by amplifying AHR activation in regulatory B cells
h-ab41908bRegional TREM2-Dependent Lipid Metabolism Determines Cortical Vulnerability in Alzheimer's Disease
TREM2 neuroinflammation 72%TREM2 R47H increases AD risk ~3-fold
h-1eaa052225TGF-β1–SMAD2/3 Axis as Master Suppressor of Microglial Trained Immunity
TGFBR1/TGFBR2 → SMAD4 → SMAD2/3 neuroinflammation 71%53% posterior · 1 signalTGF-β as key astrocyte-derived factor promoting anti-inflammatory microglial phenotype in ALS
h-fcd38787PGE2–EP2–cAMP–PKA Axis Displaces Pathological Microglial Memory Traces
PTGER2 (EP2) → ADCY → cAMP → PRKA (PKA) → SIRT1 neuroinflammation 68%53% posterior · 1 signalPGE2-EP2 signaling suppresses microglial inflammation via cAMP/PKA
h-be9bab57Autophagy-Lysosomal Degradation of IBA1 in Stressed Microglia
LC3/P62/SQSTM1 neuroinflammation 68%53% posterior · 1 signalAmmonia induces autophagy in astrocytes
h-d7924e2bc6NLRP3/Mitophagy Coupling Modulation
NLRP3 neuroinflammation 68%53% posterior · 1 signalParkin regulates microglial NLRP3 and represses neurodegeneration in PD
h-f10d82a7Chronic cGAS/STING Hyperactivation Drives Progressive Neurodegeneration Through Sustained Type I Interferon Signaling
cGAS (CGAS) / STING (TMEM173) / IFNAR1/2 neuroinflammation 66%TDP-43 directly interacts with mitochondrial membranes and disrupts mtDNA packaging
h-20db7feba4Astrocyte IL-1β as Paracrine Mediator of Microglial Complement Expression
IL1B; IL1R1; MYD88 neuroinflammation 66%53% posterior · 1 signalIL-1β upregulates C3 in brain cells via NF-κB
h-81349dd293C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward Neurotoxic Loop
C3AR1, C3, NFKB1 neuroinflammation 65%53% posterior · 1 signalTranscriptome analysis demonstrates C3/C3aR/NF-κB signaling induces A1 astrocytes after ischemic stroke
h-48b29b62IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral Tolerance Through Macrophage Reprogramming
IL10, CSF1R, CD40 neuroinflammation 65%PubMed search found: Association Between IL10 Polymorphisms and the Susceptibility to Sepsis: A Meta-Analysis.
h-88e23c4aEpigenetic Silencing of AIF1 Gene Locus by Chronic Inflammation
DNMT1/DNMT3A neuroinflammation 64%Inflammatory memory/epigenetic programming established in microglia
h-67d4435cb5Liver-Derived Inflammatory Suppressors Downregulate Microglial IBA1
STAT3/JAK1 neuroinflammation 63%53% posterior · 1 signalLiver disease produces systemic immunosuppressive cytokines
h-246051ec90C1Q-Triggered NLRP3 Inflammasome Assembly in Plaque Macrophages
C1QA/C1QC neuroinflammation 63%53% posterior · 1 signalSyk kinase links complement activation to NLRP3 inflammasome signaling
h-1ac3dd5b75Metabolic Rewiring via SPP1-Induced HIF1α Glycolytic Shift
HIF1A (HIF1α), MTOR (mTORC1), EGLN1 (PHD2) neuroinflammation 62%53% posterior · 1 signalMicroglial glycolysis drives pro-inflammatory activation
h-a93292f54fC1Q-Induced Foam Cell Formation via Scavenger Receptor Upregulation
C1QA/C1QC neuroinflammation 62%53% posterior · 1 signalC1Q enhances LDL uptake by monocytes
h-9318aa358dAge-Accelerated miR-155 Upregulation Primes Nigral Microglia for Parkinson's Disease Pathology
miR-155 neuroinflammation 61%53% posterior · 1 signalmiR-155 knockout mice show reduced neuroinflammation in MPTP models
h-42f8fa19ebMicroglial priming is primarily epigenetic, with metabolic changes acting as coupled consequences or cofactors
KDM6B neuroinflammation 61%53% posterior · 1 signalInnate immune priming can establish persistent epigenomic memory at inflammatory regulatory elements.
h-0b67a9f249STING Antagonism Prevents Acute-to-Chronic Neuroinflammation Transition via Interruption of IFN-I Feedback Looping
TMEM173 (STING) neuroinflammation 60%Single-nucleus RNA-seq shows TBI-dependent microglial STING activation and IFN-I responses at 7 dpi
h-ed960965