Hypothesis corpus
Scored, debated, and tradable. Each hypothesis carries composite, novelty, impact, mechanistic, druggability, and safety scores — plus a live market price when a collider is open.
Showing translational-neuroscience hypotheses, sorted by Composite score.
Creatine Kinase System Capacity as Neural Energy Reserve Biomarker
CKB translational-neuroscience 71%Bioenergetic failure is central to neurodegeneration
h-587ea473GLUT1-Mediated Glucose Flux Coefficient as Neuroprotection Indicator
SLC2A1 translational-neuroscience 68%53% posterior · 1 signalGLUT1 reductions exacerbate Alzheimer's vasculo-neuronal dysfunction
h-31980740Dynamic Lactate-Pyruvate Ratio as Therapeutic Stratification Biomarker
SLC16A1 translational-neuroscience 68%53% posterior · 1 signalCSF lactate levels correlate with neurodegeneration severity in dementias
h-ea5794f9Choline Kinase Activity as Membrane Integrity Response Indicator
CHKA translational-neuroscience 66%58% posterior · 2 signalsCholesterol metabolism alterations occur in Huntington's disease
h-5b0ebb1fMitochondrial ATP/ADP Carrier Activity as Bioenergetic Recovery Metric
SLC25A4 translational-neuroscience 64%53% posterior · 1 signalSLC25A mitochondrial carriers serve as biomarkers of dysfunction
h-f7da6372Purine Salvage Pathway Flux as Neuroprotection Efficacy Marker
HPRT1 translational-neuroscience 57%53% posterior · 1 signalMitochondrial DNA repair defects in neurodegeneration affect nucleotide metabolism
h-b2706086Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammation-Metabolism Interface Biomarker
LDHA, TREM2 translational-neuroscience 53%Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease.
h-5afacdfeMitochondrial Biogenesis Rate as a Dynamic Biomarker of Neuroprotection
TFAM, MT-CO1 translational-neuroscience 50%Autophagy deficiency abolishes liver mitochondrial DNA segregation.
h-28d5b559