Version history

{
  "description": "TDP-43 undergoes liquid-liquid phase separation that becomes pathological. Small molecules targeting phase separation properties could be therapeutic but the design principles are undefined.",
  "domain": "neurodegeneration",
  "status": "partially_addressed",
  "priority_score": 0.83,
  "importance_score": 0.9,
  "tractability_score": 0.65,
  "novelty_score": 0.8,
  "composite_score": 0.7109,
  "estimated_effort": "high",
  "source": "auto_detected",
  "evidence_summary": "{\"hypothesis_matches\": [{\"id\": \"h-27bc0569\", \"title\": \"Liquid-Liquid Phase Separation Modifier Therapy\", \"target_gene\": \"G3BP1\", \"target_pathway\": \"Stress granule assembly / liquid-liquid phase separation\", \"match_score\": 0.5, \"composite_score\": 0.4141533204831823, \"status\": \"proposed\"}, {\"id\": \"h-7693c291\", \"title\": \"RNA-Binding Competition Therapy for TDP-43 Cross-Seeding\", \"target_gene\": \"TARDBP\", \"target_pathway\": \"TDP-43 RNA-binding / liquid-liquid phase separation cross-seeding\", \"match_score\": 0.3, \"composite_score\": 0.3721712615349977, \"status\": \"proposed\"}, {\"id\": \"h-4fabd9ce\", \"title\": \"Cryptic Exon Silencing Restoration\", \"target_gene\": \"TARDBP\", \"target_pathway\": \"TDP-43 RNA processing / phase separation\", \"match_score\": 0.2, \"composite_score\": 0.47657825606204984, \"status\": \"proposed\"}, {\"id\": \"h-eea667a9\", \"title\": \"Cross-Seeding Prevention Strategy\", \"target_gene\": \"TARDBP\", \"target_pathway\": \"TDP-43 RNA processing / phase separation\", \"match_score\": 0.2, \"composite_score\": 0.4489384550402495, \"status\": \"proposed\"}, {\"id\": \"h-7e846ceb\", \"title\": \"Glycine-Rich Domain Competitive Inhibition\", \"target_gene\": \"TARDBP\", \"target_pathway\": \"TDP-43 RNA processing / phase separation\", \"match_score\": 0.2, \"composite_score\": 0.4240845602343659, \"status\": \"proposed\"}], \"total_matching_hypotheses\": 5, \"gap_tokens_sample\": [\"ALS-FTD\", \"TDP-43\", \"als-ftd\", \"becomes\", \"design\", \"liquid\", \"liquid-liquid\", \"molecules\", \"pathological\", \"phase\", \"principles\", \"properties\", \"separation\", \"small\", \"targeting\"], \"updated_at\": \"2026-04-06T08:21:05.714346+00:00\"}",
  "market_price": 0.5
}