What determines the threshold effects and cooperative binding dynamics that govern protein network compensation?

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Description

The skeptic correctly identified that binary interaction maps miss the non-linear, concentration-dependent nature of compensatory networks. This mechanistic gap prevents accurate prediction of which tissues can buffer genetic variants.

Source: Debate session sess_SDA-2026-04-08-gap-pubmed-20260406-062222-b5f44522 (Analysis: SDA-2026-04-08-gap-pubmed-20260406-062222-b5f44522)

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